Prospects of optical biosensors for emerging label-free RNA analysis

Carrascosa, Laura G., Huertas, César S. and Lechuga, Laura M. (2016) Prospects of optical biosensors for emerging label-free RNA analysis. Trends in Analytical Chemistry, 80 177-189. doi:10.1016/j.trac.2016.02.018


Author Carrascosa, Laura G.
Huertas, César S.
Lechuga, Laura M.
Title Prospects of optical biosensors for emerging label-free RNA analysis
Journal name Trends in Analytical Chemistry   Check publisher's open access policy
ISSN 0165-9936
Publication date 2016-06-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.trac.2016.02.018
Open Access Status Not Open Access
Volume 80
Start page 177
End page 189
Total pages 13
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract RNA is critical in countless cellular processes, and researchers are constantly discovering new types and attributing them different roles. Consequently, a growing interest in efficient RNA analysis has arisen. However, RNA detection is complicated and generally requires the use of labels. Major efforts are being devoted to conceive new approaches for RNA analysis with no need of markers. Optical biosensing is a highly sensitive approach that circumvents many of conventional methods' limitations. Lately, label-free applications with optical biosensors have been developed for short as well as for long RNAs. The low limits of detection at the pM level enabled by optical biosensors, together with a fast analysis, their reusability and the label-free scheme of operation, clearly highlight them among the most promising next-generation RNA screening platforms. This review covers the most relevant optical biosensor platforms and their potential for enabling sensitive and label-free RNA analysis.
Keyword Label-free detection
Microdevices
Optical biosensor
Plasmonics
RNA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 12 Apr 2016, 00:15:17 EST by System User on behalf of Learning and Research Services (UQ Library)