Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies

Escudero, Carlos A., Herlitz, Kurt, Troncoso, Felipe, Acurio, Jesenia, Aguayo, Claudio, Roberts, James M., Truong, Grace, Duncombe, Gregory, Rice, Gregory and Salomon, Carlos (2016) Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies. Frontiers in Physiology, 7 98: 1-17. doi:10.3389/fphys.2016.00098

Author Escudero, Carlos A.
Herlitz, Kurt
Troncoso, Felipe
Acurio, Jesenia
Aguayo, Claudio
Roberts, James M.
Truong, Grace
Duncombe, Gregory
Rice, Gregory
Salomon, Carlos
Title Role of extracellular vesicles and microRNAs on dysfunctional angiogenesis during preeclamptic pregnancies
Journal name Frontiers in Physiology   Check publisher's open access policy
ISSN 1664-042X
Publication date 2016-03
Year available 2016
Sub-type Article (original research)
DOI 10.3389/fphys.2016.00098
Open Access Status DOI
Volume 7
Issue 98
Start page 1
End page 17
Total pages 17
Place of publication Lausanne, Switzerland
Publisher Frontiers Research Foundation
Collection year 2017
Language eng
Abstract Preeclampsia is a syndrome characterized by hypertension during pregnancy, which is a leading cause of morbidity and mortality in both mother and newborn in developing countries. Some advances have increased the understanding of pathophysiology of this disease. For example, reduced utero-placental blood flow associated with impaired trophoblast invasion may lead to a hypoxic placenta that releases harmful materials into the maternal and feto-placental circulation and impairs endothelial function. Identification of these harmful materials is one of the hot topics in the literature, since these provide potential biomarkers. Certainty, such knowledge will help us to understand the miscommunication between mother and fetus. In this review we highlight how placental extracellular vesicles and their cargo, such as small RNAs (i.e., microRNAs), might be involved in endothelial dysfunction, and then in the angiogenesis process, during preeclampsia. Currently only a few reports have addressed the potential role of endothelial regulatory miRNA in the impaired angiogenesis in preeclampsia. One of the main limitations in this area is the variability of the analyses performed in the current literature. This includes variability in the size of the particles analyzed, and broad variation in the exosomes considered. The quantity of microRNA targets genes suggest that practically all endothelial cell metabolic functions might be impaired. More studies are required to investigate mechanisms underlying miRNA released from placenta upon endothelial function involved in the angiogenenic process.
Keyword Preeclampsia
Endothelial dysfunction
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Faculty of Medicine and Biomedical Sciences Publications
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