Biosensing made easy with PEG-targeted bi-specific antibodies

Raftery, Lyndon J., Grewal, Yadveer S., Howard, Christopher B., Jones, Martina L., Shiddiky, Muhammad J. A., Carrascosa, Laura G., Thurecht, Kristofer J., Mahler, Stephen M. and Trau, Matt (2016) Biosensing made easy with PEG-targeted bi-specific antibodies. Chemical Communications, 52 33: 5730-5733. doi:10.1039/C6CC01916A

Author Raftery, Lyndon J.
Grewal, Yadveer S.
Howard, Christopher B.
Jones, Martina L.
Shiddiky, Muhammad J. A.
Carrascosa, Laura G.
Thurecht, Kristofer J.
Mahler, Stephen M.
Trau, Matt
Title Biosensing made easy with PEG-targeted bi-specific antibodies
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
Publication date 2016-04-28
Year available 2016
Sub-type Article (original research)
DOI 10.1039/C6CC01916A
Open Access Status Not Open Access
Volume 52
Issue 33
Start page 5730
End page 5733
Total pages 4
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2017
Language eng
Abstract Whilst recent advances in nanotechnology have yielded many new biosensing capabilities, innovative biological attachment and detection modalities remain relatively underdeveloped. Bi-specific antibodies (bsAbs) – which exhibit binding capability for two separate targets – offer an inherent advantage over conventional antibody reagents by significantly simplifying sensor surface preparation. Herein, we report the deployment of bsAbs for simultaneous attachment to a polymer-coated transducer and label-free, electrochemical (EC) detection of target antigens.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

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Created: Fri, 08 Apr 2016, 09:29:45 EST by Mrs Louise Nimwegen on behalf of Aust Institute for Bioengineering & Nanotechnology