HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis

Zacchi, Lucia F., Schulz, Wade L. and Davis, Dana A. (2010) HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis. PLoS One, 5 8: e12171.1-e12171.7. doi:10.1371/journal.pone.0012171


Author Zacchi, Lucia F.
Schulz, Wade L.
Davis, Dana A.
Title HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis
Formatted title
HOS2 and HDA1 encode histone deacetylases with opposing roles in Candida albicans morphogenesis
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2010
Sub-type Article (original research)
DOI 10.1371/journal.pone.0012171
Open Access Status DOI
Volume 5
Issue 8
Start page e12171.1
End page e12171.7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract Epigenetic mechanisms regulate the expression of virulence traits in diverse pathogens, including protozoan and fungi. In the human fungal pathogen Candida albicans, virulence traits such as antifungal resistance, white-opaque switching, and adhesion to lung cells are regulated by histone deacetylases (HDACs). However, the role of HDACs in the regulation of the yeast-hyphal morphogenetic transitions, a critical virulence attribute of C. albicans, remains poorly explored. In this study, we wished to determine the relevance of other HDACs on C. albicans morphogenesis. We generated mutants in the HDACs HOS1, HOS2, RPD31, and HDA1 and determined their ability to filament in response to different environmental stimuli. We found that while HOS1 and RPD31 have no or a more limited role in morphogenesis, the HDACs HOS2 and HDA1 have opposite roles in the regulation of hyphal formation. Our results demonstrate an important role for HDACs on the regulation of yeast-hyphal transitions in the human pathogen C. albicans.
Keyword Candida albicans
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Thu, 07 Apr 2016, 21:17:57 EST by Lucia Zacchi on behalf of School of Chemistry & Molecular Biosciences