Cancer cell antiproliferation activity and metabolism of black carrot anthocyanins

Netzel, Michael, Netzel, Gabriele, Kammerer, Dietmar R., Schieber, Andreas, Carle, Reinhold, Simons, Lloyd, Bitsch, Inngard, Bitsch, Roland and Konczak, Lzabela (2007) Cancer cell antiproliferation activity and metabolism of black carrot anthocyanins. Innovative Food Science and Emerging Technologies, 8 3: 365-372. doi:10.1016/j.ifset.2007.03.011


Author Netzel, Michael
Netzel, Gabriele
Kammerer, Dietmar R.
Schieber, Andreas
Carle, Reinhold
Simons, Lloyd
Bitsch, Inngard
Bitsch, Roland
Konczak, Lzabela
Title Cancer cell antiproliferation activity and metabolism of black carrot anthocyanins
Journal name Innovative Food Science and Emerging Technologies   Check publisher's open access policy
ISSN 1466-8564
Publication date 2007
Sub-type Article (original research)
DOI 10.1016/j.ifset.2007.03.011
Volume 8
Issue 3
Start page 365
End page 372
Total pages 8
Language eng
Subject 1106 Human Movement and Sports Science
1305 Biotechnology
Abstract The antiproliferation activity of a black carrot anthocyanin-rich extract (BC-ARE) on human cancer cells (HT-29 colorectal adenocarcinoma and HL-60 promyelocytic leukaemia) and metabolism of its characteristic anthocyanins (acylated and nonacylated forms) in humans were investigated. Cancer cells were exposed for 24 h to 0.0-2.0 mg/mL of BC-ARE. Anthocyanin-rich extract inhibited proliferation of both types of cancer cells in a dose-dependent manner. After ingestion of a black carrot concentrate, three acylated and two nonacylated anthocyanins were excreted in the volunteers (n = 4) urine (0.048% of the administered dose). The anthocyanins were characterized by HPLC-DAD-ESI-MS/MS. Urine recovery of nonacylated anthocyanins was 8-fold higher than that of acylated anthocyanins. Industrial relevance: Natural pigments have achieved commercial significance as food colorants due to the fact that consumers perceive them as safe additives. At present extracts rich in acylated anthocyanins, which are known for their outstanding stability, serve as a major source of natural food colours for the food colorant industry with purple sweetpotato, red cabbage and black carrot being the major sources. Beside aesthetic values, anthocyanins possess enhanced physiological activity due to their potent antioxidant properties and enhance the health-promoting qualities of foods. Our findings on cancer cell antiproliferation activity of an anthocyanin-rich black carrot extract as well as information about the bioavailability of black carrot anthocyanins could lead to an increased application of these natural food colorants by the food industry.
Keyword Anthocyanins
Antiproliferation activity
Black carrot concentrate
Humans
Metabolism
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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