Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract

Frank, T, Janssen, M, Netzel, M, Strass, G, Kler, A, Kriesl, E and Bitsch, I (2005) Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract. Journal of Clinical Pharmacology, 45 2: 203-210. doi:10.1177/0091270004270561


Author Frank, T
Janssen, M
Netzel, M
Strass, G
Kler, A
Kriesl, E
Bitsch, I
Title Pharmacokinetics of anthocyanidin-3-glycosides following consumption of Hibiscus sabdariffa L. extract
Journal name Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0091-2700
1552-4604
Publication date 2005-02
Sub-type Article (original research)
DOI 10.1177/0091270004270561
Open Access Status Not Open Access
Volume 45
Issue 2
Start page 203
End page 210
Total pages 8
Place of publication Wiley-Blackwell Publishing
Publisher Hoboken, United States
Language eng
Abstract Pharmacokinetic parameters of several dietary anthocyanins following consumption of Hibiscus sabdariffa L. extract were determined in 6 healthy volunteers. Subjects were given a single oral dose of 150 mL of Hibiscus sabdariffa L. extract yielding 62.6 mg of cyanidin-3-sambubioside, 81.6 mg of delphindin-3-sambubioside, and 147.4 mg of total anthocyanins (calculated as cyanidin equivalents). Within 7 hours, the urinary excretion of cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins (ie, the sum of all quantifiable anthocyanidin glycosides) was 0.016%, 0.021%, and 0.018% of the administered doses, respectively. Maximum excretion rates were determined at 1.5 to 2.0 hours after intake. The dose-normalized plasma area under the curve estimates were 0.076, 0.032, and 0.050 ng•h/mL/mg for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The dose-normalized Cmax estimates were 0.036, 0.015, and 0.023 ng/mL/mg in the same sequence. They were reached each at 1.5 hours (median) after intake. The geometric means of t1/2 were 2.18, 3.34, and 2.63 hours for cyanidin-3-sambubioside, delphinidin-3-sambubioside, and total anthocyanins, respectively. The urinary excretion of intact anthocyanins was fast and appeared to be monoexponential. To evaluate the contribution of anthocyanins to the health-protecting effects of Hibiscus sabdariffa L. extract, it will be necessary to perform further studies on both the intact glycosides and their in vivo metab-olites or conjugates in human plasma and urine.
Keyword Anthocyanidin-3-glycosides
Anthocyanins
Herbal medicine
Hibiscus sabdariffa L. extract
Pharmacokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Centre for Nutrition and Food Sciences Publications
 
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