The effect of multi-echo imaging and resolution in functional MRI of the basal ganglia

Palmer, Jake (2015). The effect of multi-echo imaging and resolution in functional MRI of the basal ganglia Honours Thesis, School of Psychology, The University of Queensland.

       
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Author Palmer, Jake
Thesis Title The effect of multi-echo imaging and resolution in functional MRI of the basal ganglia
School, Centre or Institute School of Psychology
Institution The University of Queensland
Publication date 2015-10-07
Thesis type Honours Thesis
Supervisor Ross Cunnington
Total pages 67
Language eng
Subjects 1701 Psychology
Formatted abstract
Two issues associated with fMRI of the basal ganglia are their small, dense and highly interconnected structure, and the high iron content. Therefore, this study aims to address these issues through the application of multi-echo imaging, which may compensate for the signal loss associated with high iron content, and by assessing the effect of resolution on sensitivity to changes in BOLD signal. Ten healthy participants completed complex motor task designed to produce differential activation throughout the basal ganglia motor network. The key comparisons assessed were between single-echo and multi-echo sequences at the same resolution and the comparison of single-echo sequences at 2.5mm3, 1.3mm3 and 1.0mm3 resolutions. Overall, the results showed the multi-echo sequence to be more sensitive to changes in BOLD signal compared to the single-echo sequence, while the 2.5mm3 resolution was found to be more sensitive to changes in BOLD signal than both the 1.3mm3 and 1.0mm3 resolutions. Based on these results, qualitative investigation of the data and a discussion of the limitations of the study, multi-echo imaging at standard resolution is recommended for general sensitivity to changes in activation, while multi-echo imaging at higher resolution is recommended when increased spatial specificity is required for imaging the basal ganglia
Keyword MRI
Basal ganglia
Multi-echo imaging
Resolution

 
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Created: Thu, 07 Apr 2016, 00:35:19 EST by Lisa Perry on behalf of School of Psychology