Statin intolerance - an attempt at a unified definition. position paper from an International Lipid Expert Panel

Banach, Maciej, Rizzo, Manfredi, Toth, Peter P., Farnier, Michel, Davidson, Michael H., Al-Rasadi, Khalid, Aronow, Wilbert S., Athyros, Vasilis, Djuric, Dragan M., Ezhov, Marat V., Greenfield, Robert S., Hovingh, G. Kees, Kostner, Karam, Serban, Corina, Lighezan, Daniel, Fras, Zlatko, Moriarty, Patrick M., Muntner, Paul, Goudev, Assen, Ceska, Richard, Nicholls, Stephen J., Broncel, Marlena, Nikolic, Dragana, Pella, Daniel, Puri, Raman, Rysz, Jacek, Wong, Nathan D., Bajnok, Laszlo, Jones, Steven R., Ray, Kausik K. and Mikhailidis, Dimitri P. (2015) Statin intolerance - an attempt at a unified definition. position paper from an International Lipid Expert Panel. Expert Opinion on Drug Safety, 14 6: 935-955.

Author Banach, Maciej
Rizzo, Manfredi
Toth, Peter P.
Farnier, Michel
Davidson, Michael H.
Al-Rasadi, Khalid
Aronow, Wilbert S.
Athyros, Vasilis
Djuric, Dragan M.
Ezhov, Marat V.
Greenfield, Robert S.
Hovingh, G. Kees
Kostner, Karam
Serban, Corina
Lighezan, Daniel
Fras, Zlatko
Moriarty, Patrick M.
Muntner, Paul
Goudev, Assen
Ceska, Richard
Nicholls, Stephen J.
Broncel, Marlena
Nikolic, Dragana
Pella, Daniel
Puri, Raman
Rysz, Jacek
Wong, Nathan D.
Bajnok, Laszlo
Jones, Steven R.
Ray, Kausik K.
Mikhailidis, Dimitri P.
Title Statin intolerance - an attempt at a unified definition. position paper from an International Lipid Expert Panel
Journal name Expert Opinion on Drug Safety   Check publisher's open access policy
ISSN 1474-0338
Publication date 2015-06
Year available 2015
Sub-type Article (original research)
Open Access Status DOI
Volume 14
Issue 6
Start page 935
End page 955
Total pages 21
Place of publication Oxfordshire OX14 4RN United Kingdom
Publisher Taylor & Francis
Collection year 2016
Language eng
Abstract Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are musclerelated. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10-15% of patients. In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
Keyword Definition
Muscle symptoms
Risk factors
Statin intolerance
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Reprint of

Document type: Journal Article
Sub-type: Article (original research)
Collection: Mater Research Institute-UQ (MRI-UQ)
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 06 Apr 2016, 12:58:19 EST by Anthony Yeates on behalf of Scholarly Communication and Digitisation Service