D-amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus

Torres, A. M., Menz, I., Alewood, P. F., Bansal, P., Lahnstein, J., Gallagher, C. H. and Kuchel, P. W. (2002) D-amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus. Febs Letters, 524 1-3: 172-176. doi:10.1016/S0014-5793(02)03050-8


Author Torres, A. M.
Menz, I.
Alewood, P. F.
Bansal, P.
Lahnstein, J.
Gallagher, C. H.
Kuchel, P. W.
Title D-amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the Australian platypus
Journal name Febs Letters   Check publisher's open access policy
ISSN 0014-5793
Publication date 2002
Sub-type Article (original research)
DOI 10.1016/S0014-5793(02)03050-8
Volume 524
Issue 1-3
Start page 172
End page 176
Total pages 5
Place of publication Amsterdam
Publisher Elsevier Science Bv
Language eng
Abstract The C-type natriuretic peptide from the platypus venom (OvCNP) exists in two forms, OvCNPa and OvCNPb, whose amino acid sequences are identical. Through the use of nuclear magnetic resonance, mass spectrometry, and peptidase digestion studies, we discovered that OvCNPb incorporates a D-amino acid at position 2 in the primary structure. Peptides containing a D-amino acid have been found in lower forms of organism, but this report is the first for a D-amino acid in a biologically active peptide from a mammal. The result implies the existence of a specific isomerase in the platypus that converts an L-amino acid residue in the protein to the D-configuration. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Keyword Biochemistry & Molecular Biology
Biophysics
Cell Biology
Platypus Venom
C-type Natriuretic Peptide
D-amino Acid
Toxin
Nuclear Magnetic Resonance
Posttranslational Modification
Achatina-fulica
D-aspartate
Human Lens
D-serine
Isomerization
Spectroscopy
Cosy
Proteins
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 13 Aug 2007, 13:05:39 EST