Irradiation and combination immunotherapy

Barkauskas, Deborah S. and Smyth, Mark J. (2016) Irradiation and combination immunotherapy. Translational Cancer Research, 5 1: 75-78. doi:10.3978/j.issn.2218-676X.2016.01.12

Author Barkauskas, Deborah S.
Smyth, Mark J.
Title Irradiation and combination immunotherapy
Journal name Translational Cancer Research   Check publisher's open access policy
ISSN 2218-676X
Publication date 2016-02
Year available 2016
Sub-type Editorial
DOI 10.3978/j.issn.2218-676X.2016.01.12
Open Access Status DOI
Volume 5
Issue 1
Start page 75
End page 78
Total pages 4
Place of publication Hong Kong, Hong Kong
Publisher Pioneer Bioscience Publishing
Collection year 2017
Language eng
Abstract Our ability to control and eradicate cancer has advanced with new combinations of surgery, chemotherapy, irradiation therapy and recently, immunotherapy. The concept of a single cancer therapy has passed with each new discovery revealing the complexity of the genetics and immunology of the tumor microenvironment. Understanding which combination of standard and emerging therapies that can provide long lasting remission of each particular cancer is paramount. Here we review the capacity of radiation therapy (RT) combined with immune checkpoint inhibitors to induce a complete response in mammary carcinoma and melanoma (1,2) and the evaluation of therapy mechanism of action using intravital microscopy. Current tools and approaches to evaluate mechanism of action of therapies have been limited, but real time intravital imaging offers prospects of enhancing our knowledge.
Keyword Commentary
Irradiation therapy
Cancer therapy
Radiation therapy (RT)
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Editorial
Collections: HERDC Pre-Audit
School of Medicine Publications
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