Sulphate in pregnancy

Dawson, Paul A., Elliott, Aoife and Bowling, Francis G. (2015) Sulphate in pregnancy. Nutrients, 7 3: 1594-1606. doi:10.3390/nu7031594


Author Dawson, Paul A.
Elliott, Aoife
Bowling, Francis G.
Title Sulphate in pregnancy
Journal name Nutrients   Check publisher's open access policy
ISSN 2072-6643
Publication date 2015-03-04
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3390/nu7031594
Open Access Status DOI
Volume 7
Issue 3
Start page 1594
End page 1606
Total pages 13
Place of publication Basel, Switzerland
Publisher MDPI
Collection year 2016
Language eng
Formatted abstract
Sulphate is an obligate nutrient for healthy growth and development. Sulphate conjugation (sulphonation) of proteoglycans maintains the structure and function of tissues. Sulphonation also regulates the bioactivity of steroids, thyroid hormone, bile acids, catecholamines and cholecystokinin, and detoxifies certain xenobiotics and pharmacological drugs. In adults and children, sulphate is obtained from the diet and from the intracellular metabolism of sulphur-containing amino acids. Dietary sulphate intake can vary greatly and is dependent on the type of food consumed and source of drinking water. Once ingested, sulphate is absorbed into circulation where its level is maintained at approximately 300 μmol/L, making sulphate the fourth most abundant anion in plasma. In pregnant women, circulating sulphate concentrations increase by twofold with levels peaking in late gestation. This increased sulphataemia, which is mediated by up-regulation of sulphate reabsorption in the maternal kidneys, provides a reservoir of sulphate to meet the gestational needs of the developing foetus. The foetus has negligible capacity to generate sulphate and thereby, is completely reliant on sulphate supply from the maternal circulation. Maternal hyposulphataemia leads to foetal sulphate deficiency and late gestational foetal death in mice. In humans, reduced sulphonation capacity has been linked to skeletal dysplasias, ranging from the mildest form, multiple epiphyseal dysplasia, to achondrogenesis Type IB, which results in severe skeletal underdevelopment and death in utero or shortly after birth. Despite being essential for numerous cellular and metabolic functions, the nutrient sulphate is largely unappreciated in clinical settings. This article will review the physiological roles and regulation of sulphate during pregnancy, with a particular focus on animal models of disturbed sulphate homeostasis and links to human pathophysiology.
Keyword Sulphate
Sulphonation
Foetal development
Pregnancy
Gestation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
 
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