Recovery of drugs of abuse from Drager DCD5000 oral fluid collection device in Australia

Hall, Ashley-Jane, Warner, Janet V., Henman, Michael G. and Ferguson, Wendy E. (2015) Recovery of drugs of abuse from Drager DCD5000 oral fluid collection device in Australia. Journal of Analytical Toxicology, 39 2: 140-143. doi:10.1093/jat/bku123


Author Hall, Ashley-Jane
Warner, Janet V.
Henman, Michael G.
Ferguson, Wendy E.
Title Recovery of drugs of abuse from Drager DCD5000 oral fluid collection device in Australia
Journal name Journal of Analytical Toxicology   Check publisher's open access policy
ISSN 1945-2403
0146-4760
Publication date 2015-03
Year available 2015
Sub-type Article (original research)
DOI 10.1093/jat/bku123
Open Access Status Not Open Access
Volume 39
Issue 2
Start page 140
End page 143
Total pages 4
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Abstract In Australia, it is a requirement of workplace oral fluid (OF) drugs of abuse testing that drug recovery from collection devices be verified by an accredited laboratory. Recovery data are used in conjunction with collection volume imprecision data and uncertainty of measurement to provide an estimation of drug concentration in neat OF. The manufacturer's product information for the DCD5000 collection device indicates that the collection volume of the swab is 380 µL. Recovery data for the swab when used with the isopropanol provided by the manufacturer are not available. A series of experiments using fortified drug-free OF were performed to assess the collection volume imprecision of the Dräger DCD5000 swab and the recovery of drugs from the swab using isopropanol. The fortified OF was collected with the swabs (n = 16), and swabs were discharged into vials of isopropanol as per the manufacturer's instructions. The mean collection volume of the DCD5000 swab was 487 µL with an imprecision of 1.3%. Recovery of drug from the device ranged from 86 to 98% for drugs listed in the Australian OF workplace testing standard. Recovery of methadone, buprenorphine and norbuprenorphine ranged from 93 to 102%. Recovery of 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene was 45%, suggesting that urine is more suitable sample if methadone therapy is being monitored. Overall, drug recovery from the device using isopropanol was acceptable when the increased collection volume of the swab was taken into account.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
Non HERDC
 
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Created: Fri, 01 Apr 2016, 09:41:21 EST by Julia McCabe on behalf of Mater Research Institute-UQ