Clinical evaluation of alfaxalone as an anaesthetic induction agent in cats less than 12 weeks of age

O'Hagan, B, Pasloske, K, McKinnon, C, Perkins, NR and Whittem, T (2012) Clinical evaluation of alfaxalone as an anaesthetic induction agent in cats less than 12 weeks of age. Australian Veterinary Journal, 90 10: 395-401. doi:10.1111/j.1751-0813.2012.00983.x


Author O'Hagan, B
Pasloske, K
McKinnon, C
Perkins, NR
Whittem, T
Title Clinical evaluation of alfaxalone as an anaesthetic induction agent in cats less than 12 weeks of age
Journal name Australian Veterinary Journal   Check publisher's open access policy
ISSN 0005-0423
1751-0813
Publication date 2012-10
Year available 2012
Sub-type Article (original research)
DOI 10.1111/j.1751-0813.2012.00983.x
Open Access Status Not Open Access
Volume 90
Issue 10
Start page 395
End page 401
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective
To assess the clinical suitability of alfaxalone as an anaesthetic induction and maintenance agent for kittens aged less than 12 weeks.

Materials and methods
The study group comprised 34 kittens aged less than 12 weeks that were presented for surgical desexing. They were aged by dentition, examined and weighed prior to premedication with acepromazine, atropine and morphine. At 20–30 min after premedication, animals were anaesthetised with intravenous alfaxalone administered to effect, using a target maximum expected dose of 5 mg/kg. All cats were intubated: 25 were maintained with isoflurane in oxygen administered with a non-rebreathing circuit and 8 were maintained by supplemental intravenous administration of alfaxalone. Subjective measures of anaesthetic quality and vital signs were recorded from enrolment to recovery. Cats receiving supplemental alfaxalone for maintenance were evaluated for time to first supplemental dose and the total dose of supplemental alfaxalone (mg/kg/h). Descriptive and comparative statistics were used to analyse and present collected data.

Results
The mean (± SD) dose of alfaxalone for induction was 4.7 ± 0.5 mg/kg body weight. Subjective measures of anaesthetic quality indicated acceptable induction, maintenance and recovery standards. Measured cardiovascular and respiratory parameters were well maintained.

Conclusion
Alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (Alfaxan®) is a suitable injectable anaesthetic induction agent for juvenile cats aged less than 12 weeks requiring anaesthesia. Maintenance of anaesthesia with supplemental doses of alfaxalone may be a suitable alternative in kittens when the use of inhalant anaesthetic maintenance is not feasible.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 30 Mar 2016, 17:54:19 EST by Nigel Perkins on behalf of School of Veterinary Science