Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N‐acetyl glucosamine, and sodium hyaluronan

Koenig, Toby J., Dart, Andrew J., McIlwraith, Wayne, Horadogoda, Neil, Bell, Robin J., Perkins, Nigel R., Dart, Christina, Krockenberger, Mark, Jeffcott, Leo B. and Little, Christopher B. (2014) Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N‐acetyl glucosamine, and sodium hyaluronan. Veterinary Surgery, 43 5: 612-622. doi:10.1111/j.1532-950X.2014.12203.x


Author Koenig, Toby J.
Dart, Andrew J.
McIlwraith, Wayne
Horadogoda, Neil
Bell, Robin J.
Perkins, Nigel R.
Dart, Christina
Krockenberger, Mark
Jeffcott, Leo B.
Little, Christopher B.
Title Treatment of experimentally induced osteoarthritis in horses using an intravenous combination of sodium pentosan polysulfate, N‐acetyl glucosamine, and sodium hyaluronan
Journal name Veterinary Surgery   Check publisher's open access policy
ISSN 1532-950X
0161-3499
Publication date 2014-07-01
Sub-type Article (original research)
DOI 10.1111/j.1532-950X.2014.12203.x
Open Access Status Not Open Access
Volume 43
Issue 5
Start page 612
End page 622
Total pages 11
Place of publication Hoboken NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Objective
To assess the effects of sodium pentosan polysulfate (PPS), N-acetyl glucosamine (NAG), and sodium hyaluronan (HA) in horses with induced osteoarthritis (OA).

Study Design
Experimental.

Animals
Adult Standard bred horses (n = 16).

Methods
OA was induced arthroscopically in 1 intercarpal joint; 8 horses were administered 3 mg/kg PPS, 4.8 mg/kg NAG, and 0.12 mg/kg HA (PGH), intravenously (IV), weekly and 8 horses were administered an equivalent volume of saline IV until study completion (day 70). Horses underwent a standardized treadmill exercise program. Clinical and radiographic findings and synovial fluid analysis were evaluated throughout the study. Macroscopic, histologic, histochemical, and biochemical findings were evaluated after necropsy. Comparisons of interest included OA and non-OA joints of saline treated horses and OA joints of PGH treated horses and OA joints of saline treated horses. Results were statistically analyzed with significance set at P < .05.

Results
OA caused increases in clinical assessment scores, synovial fluid variables, radiographic, macroscopic, and histologic cartilage scores, synovial fluid and cartilage chondroitin sulfate 846-epitope and glycosaminoglycan concentration. Total radiographic scores, total macroscopic joint pathology and macroscopic cartilage pathology scores were significantly reduced in horses treated with PGH compared with saline treated horses. Synovial fluid total protein concentration and white blood cell count were higher in OA joints of PGH treated horses compared with saline treated horses. There were no other significant differences between treatment groups.

Conclusions
Improvements in macroscopic variables were not supported by other outcomes. Further evidence is needed before PGH can be recommended as a therapeutic option for osteoarthritis in horses.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 30 Mar 2016, 17:30:49 EST by Nigel Perkins on behalf of School of Veterinary Science