Neuropeptide immunoreactivity and co-existence in cardiovascular nerves and autonomic ganglia of the estuarine crocodile, Crocodylus porosus, and cardiovascular effects of neuropeptides

Karila, P, Axelsson, M, Franklin, CE, Fritsche, R, Gibbins, IL, Grigg, GC, Nilsson, S and Holmgren, S (1995) Neuropeptide immunoreactivity and co-existence in cardiovascular nerves and autonomic ganglia of the estuarine crocodile, Crocodylus porosus, and cardiovascular effects of neuropeptides. Regulatory Peptides, 58 1-2: 25-39. doi:10.1016/0167-0115(95)00055-G


Author Karila, P
Axelsson, M
Franklin, CE
Fritsche, R
Gibbins, IL
Grigg, GC
Nilsson, S
Holmgren, S
Title Neuropeptide immunoreactivity and co-existence in cardiovascular nerves and autonomic ganglia of the estuarine crocodile, Crocodylus porosus, and cardiovascular effects of neuropeptides
Journal name Regulatory Peptides   Check publisher's open access policy
ISSN 0167-0115
Publication date 1995-07-21
Sub-type Article (original research)
DOI 10.1016/0167-0115(95)00055-G
Volume 58
Issue 1-2
Start page 25
End page 39
Total pages 15
Language eng
Subject 1303 Specialist Studies in Education
1308 Clinical Biochemistry
1310 Endocrinology
1314 Physiology
2804 Cellular and Molecular Neuroscience
2800 Neuroscience
Abstract The two aortas of the crocodile are in open connection at two sites, the foramen of Panizzae immediately outside the ventricles, and the arterial anastomosis at the level of the gut. The present study was performed to elucidate the innervation of the cardiovascular structures of the crocodile, in part to provide a further basis for the assumption that the apertures of the foramen and the anastomosis may be altered, possibly leading to changes in the flow profiles of the central vessels. The presence of smooth muscle arranged at the circumference of the foramen and in the walls of the anastomosis was demonstrated. The cardiovascular structures were innervated by nerves containing co-existing tyrosine hydroxylase, NPY and somatostatin immunoreactivities, which also occurred in neurons of the sympathetic ganglia. CGRP and substance P immunoreactive material co-existed in cardiovascular nerves, and in the nodose ganglion. In addition, bombesin, VIP and galanin immunoreactive nerves were found. Effects of neuropeptides on blood flows and blood pressures were studied in vivo. Substance P increased all blood flows measured, NPY increased the flow through the arterial anastomosis while neurotensin caused an initial decrease in the flow through the arterial anastomosis. In conclusion, there is a rich innervation of the heart and major vessels of the estuarine crocodile, including the foramen of Panizza and the arterial anastomosis. These nerves possibly regulate the distribution of blood in the cardiovascular system, which is further suggested by the results of the injection of neuropeptides.
Keyword Bombesin
CGRP
Galanin
Neuropeptide Y
Neurotensin
Somatostatin
Substance P
Tyrosine hydroxylase
VIP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 29 Mar 2016, 17:23:29 EST by Gail Walter