Natural functions and structure-activity relationships of cyclotides

Oguis, Georgianna Kae, Kan, Meng-Wei and Craik, David J. (2015) Natural functions and structure-activity relationships of cyclotides. Advances in Botanical Research, 76 187-226. doi:10.1016/bs.abr.2015.10.001


Author Oguis, Georgianna Kae
Kan, Meng-Wei
Craik, David J.
Title Natural functions and structure-activity relationships of cyclotides
Journal name Advances in Botanical Research   Check publisher's open access policy
ISSN 0065-2296
ISBN 9780128000304
Publication date 2015
Year available 2015
Sub-type Article (original research)
DOI 10.1016/bs.abr.2015.10.001
Open Access Status Not yet assessed
Volume 76
Start page 187
End page 226
Total pages 40
Place of publication Maryland Heights, United States
Publisher Academic Press
Language eng
Formatted abstract
Cyclotides have a diverse range of biological activities that have both pharmaceutical and agricultural applications. Here we examine the range of activities seen in natural cyclotides and describe the structure–activity relationship (SAR) studies that have helped to understand the mechanisms associated with these activities. These SAR studies have also led to the development of “designer” cyclotides with an introduced range of pharmaceutical bioactivities. Overall, cyclotides continue to be of interest for their potential in drug design and crop protection.
Keyword Bioassay
Biological activity
Cyclic peptides
Cyclotides
Drug design
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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