Peptide-decorated dendrimers and their bioapplications

Wan, Jingjing and Alewood, Paul F. (2016) Peptide-decorated dendrimers and their bioapplications. Angewandte Chemie - International Edition, 55 17: 5124-5134. doi:10.1002/anie.201508428


Author Wan, Jingjing
Alewood, Paul F.
Title Peptide-decorated dendrimers and their bioapplications
Journal name Angewandte Chemie - International Edition   Check publisher's open access policy
ISSN 1521-3773
1433-7851
Publication date 2016-04-18
Sub-type Article (original research)
DOI 10.1002/anie.201508428
Open Access Status Not Open Access
Volume 55
Issue 17
Start page 5124
End page 5134
Total pages 11
Place of publication Weinheim, Germany
Publisher Wiley-VCH Verlag
Collection year 2017
Language eng
Abstract Peptide-decorated dendrimers (PDDs) are a class of spherical, regular, branched polymers that are modified by peptides covalently attached to their surface. PDDs have been used as protein mimetics, novel biomaterials, and in a wide range of biomedical applications. Since their design and development in the late eighties, poly-L-lysine has been a preferred core structure for PDDs. However, numerous recent innovations in polymer synthesis and ligation chemistry have re-energized the field and led to the emergence of well-defined peptide dendrimers with more diverse core structures and functions. This Minireview highlights the development of PDDs driven by significantly improved ligation chemistry incorporating structurally well-defined peptides and the emerging use of PDDs in imaging and drug development.
Keyword Conjugation chemistry
Dendrimers
Drug delivery
Multivalency
Peptides
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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