Stable ultrathin-shell double emulsions for controlled release

Zhao, Chun-Xia, Chen, Dong, Hui, Yue, Weitz, David A. and Middelberg, Anton P. J. (2016) Stable ultrathin-shell double emulsions for controlled release. ChemPhysChem, 17 11: 1553-1556. doi:10.1002/cphc.201600142

Author Zhao, Chun-Xia
Chen, Dong
Hui, Yue
Weitz, David A.
Middelberg, Anton P. J.
Title Stable ultrathin-shell double emulsions for controlled release
Journal name ChemPhysChem   Check publisher's open access policy
ISSN 1439-7641
Publication date 2016-06-03
Year available 2016
Sub-type Article (original research)
DOI 10.1002/cphc.201600142
Open Access Status Not Open Access
Volume 17
Issue 11
Start page 1553
End page 1556
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag GmbH & Co. KGaA
Collection year 2017
Language eng
Abstract Double emulsions are normally considered as metastable systems and this limit in stability restricts their applications. To enhance their stability, the outer shell can be converted into a mechanically strong layer, for example, a polymeric layer, thus allowing improved performance. This conversion can be problematic for food and drug applications, as a toxic solvent is needed to dissolve the polymer in the middle phase and a high temperature is required to remove the solvent. This process can also be highly complex, for example, involving UV initiation of polymeric monomer crosslinking. In this study, we report the formation of biocompatible, water-in-oil-in-water (W/O/W) double emulsions with an ultrathin layer of fish oil. We demonstrate their application for the encapsulation and controlled release of small hydrophilic molecules. Without a trigger, the double emulsions remained stable for months, and the release of small molecules was extremely slow. In contrast, rapid release was achieved by osmolarity shock, leading to complete release within 2 h. This work demonstrates the significant potential of double emulsions, and provides new insights into their stability and practical applications.
Keyword Double emulsions
Metastable systems
Polymeric layer
Surface chemistry
Biocompatible ultrathin-shell W/O/W double emulsions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
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