A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

De Vries, P.S., Chasman, D.I., Sabater-Lleal, M., Chen, M.-H., Huffman, J.E., Steri, M., Tang, W., Teumer, A., Marioni, R.E., Grossmann, V., Hottenga, J.J., Trompet, S., Muller-Nurasyid, M., Zhao, J.H., Brody, J.A., Kleber, M.E., Guo, X., Wang, J.J., Auer, P.L., Attia, J.R., Yanek, L.R., Ahluwalia, T.S., Lahti, J., Venturini, C., Tanaka, T., Bielak, L.F., Joshi, P.K., Rocanin-Arjo, A., Kolcic, I., Navarro, P., Rose, L.M., Oldmeadow, C., Riess, H., Mazur, J., Basu, S., Goel, A., Yang, Q., Ghanbari, M., Gonnekewillemsen, Rumley, A., Fiorillo, E., De Craen, A.J.M., Grotevendt, A., Scott, R., Taylor, K.D., Delgado, G.E., Yao, J., Kifley, A., Kooperberg, C., Qayyum, R., Lopez, L., Berentzen, T.L., Raikkonen, K., Massimomangino, Bandinelli, S., Peyser, P.A., Wild, S., Tregouet, D.-A., Wright, A.F., Marten, J., Zemunik, T., Morrison, A.C., Sennblad, B., Tofler, G., De Maat, M.P.M., De Geus, E.J.C., Lowe, G.D., Zoledziewska, M., Sattar, N., Binder, H., Volker, U., Waldenberger, M., Khaw, K.-T., Mcknight, B., Huang, J., Jenny, N.S., Holliday, E.G., Qi, L., Mcevoy, M.G., Becker, D.M., Starr, J.M., Sarin, A.-P., Hysi, P.G., Hernandez, D.G., Jhun, M.A., Campbell, H., Hamsten, A., Sarin, F., Mcardle, W.L., Eline Slagboom, P., Zeller, T., Koenig, W., Psaty, B., Haritunians, T., Liu, J., Palotie, A., Uitterlinden, A.G., Stott, D.J., Hofman, A., Franco, O.H., Polasek, O., Rudan, I., Morange, P.-E., Wilson, J.F., Kardia, S.L.R., Ferrucci, L., Spector, T.D., Eriksson, J.G., Hansen, T., Deary, I.J., Becker, L.C., Scott, R.J., Mitchell, P., Marz, W., Wareham, N.J., Peters, A., Greinacher, A., Wild, P.S., Wouter Jukema, J., Boomsma, D.I., Hayward, C., Cucca, F., Tracy, R., Watkins, H., Reiner, A.P., Folsom, A.R., Ridker, P.M., O'Donnell, C.J., Smith, N.L., Strachan, D.P. and Dehghan, A. (2016) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25 2: 358-370. doi:10.1093/hmg/ddv454

Author De Vries, P.S.
Chasman, D.I.
Sabater-Lleal, M.
Chen, M.-H.
Huffman, J.E.
Steri, M.
Tang, W.
Teumer, A.
Marioni, R.E.
Grossmann, V.
Hottenga, J.J.
Trompet, S.
Muller-Nurasyid, M.
Zhao, J.H.
Brody, J.A.
Kleber, M.E.
Guo, X.
Wang, J.J.
Auer, P.L.
Attia, J.R.
Yanek, L.R.
Ahluwalia, T.S.
Lahti, J.
Venturini, C.
Tanaka, T.
Bielak, L.F.
Joshi, P.K.
Rocanin-Arjo, A.
Kolcic, I.
Navarro, P.
Rose, L.M.
Oldmeadow, C.
Riess, H.
Mazur, J.
Basu, S.
Goel, A.
Yang, Q.
Ghanbari, M.
Rumley, A.
Fiorillo, E.
De Craen, A.J.M.
Grotevendt, A.
Scott, R.
Taylor, K.D.
Delgado, G.E.
Yao, J.
Kifley, A.
Kooperberg, C.
Qayyum, R.
Lopez, L.
Berentzen, T.L.
Raikkonen, K.
Bandinelli, S.
Peyser, P.A.
Wild, S.
Tregouet, D.-A.
Wright, A.F.
Marten, J.
Zemunik, T.
Morrison, A.C.
Sennblad, B.
Tofler, G.
De Maat, M.P.M.
De Geus, E.J.C.
Lowe, G.D.
Zoledziewska, M.
Sattar, N.
Binder, H.
Volker, U.
Waldenberger, M.
Khaw, K.-T.
Mcknight, B.
Huang, J.
Jenny, N.S.
Holliday, E.G.
Qi, L.
Mcevoy, M.G.
Becker, D.M.
Starr, J.M.
Sarin, A.-P.
Hysi, P.G.
Hernandez, D.G.
Jhun, M.A.
Campbell, H.
Hamsten, A.
Sarin, F.
Mcardle, W.L.
Eline Slagboom, P.
Zeller, T.
Koenig, W.
Psaty, B.
Haritunians, T.
Liu, J.
Palotie, A.
Uitterlinden, A.G.
Stott, D.J.
Hofman, A.
Franco, O.H.
Polasek, O.
Rudan, I.
Morange, P.-E.
Wilson, J.F.
Kardia, S.L.R.
Ferrucci, L.
Spector, T.D.
Eriksson, J.G.
Hansen, T.
Deary, I.J.
Becker, L.C.
Scott, R.J.
Mitchell, P.
Marz, W.
Wareham, N.J.
Peters, A.
Greinacher, A.
Wild, P.S.
Wouter Jukema, J.
Boomsma, D.I.
Hayward, C.
Cucca, F.
Tracy, R.
Watkins, H.
Reiner, A.P.
Folsom, A.R.
Ridker, P.M.
O'Donnell, C.J.
Smith, N.L.
Strachan, D.P.
Dehghan, A.
Title A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 1460-2083
Publication date 2016-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/hmg/ddv454
Open Access Status Not Open Access
Volume 25
Issue 2
Start page 358
End page 370
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
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