A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

De Vries, P.S., Chasman, D.I., Sabater-Lleal, M., Chen, M.-H., Huffman, J.E., Steri, M., Tang, W., Teumer, A., Marioni, R.E., Grossmann, V., Hottenga, J.J., Trompet, S., Muller-Nurasyid, M., Zhao, J.H., Brody, J.A., Kleber, M.E., Guo, X., Wang, J.J., Auer, P.L., Attia, J.R., Yanek, L.R., Ahluwalia, T.S., Lahti, J., Venturini, C., Tanaka, T., Bielak, L.F., Joshi, P.K., Rocanin-Arjo, A., Kolcic, I., Navarro, P., Rose, L.M., Oldmeadow, C., Riess, H., Mazur, J., Basu, S., Goel, A., Yang, Q., Ghanbari, M., Gonnekewillemsen, Rumley, A., Fiorillo, E., De Craen, A.J.M., Grotevendt, A., Scott, R., Taylor, K.D., Delgado, G.E., Yao, J., Kifley, A., Kooperberg, C., Qayyum, R., Lopez, L., Berentzen, T.L., Raikkonen, K., Massimomangino, Bandinelli, S., Peyser, P.A., Wild, S., Tregouet, D.-A., Wright, A.F., Marten, J., Zemunik, T., Morrison, A.C., Sennblad, B., Tofler, G., De Maat, M.P.M., De Geus, E.J.C., Lowe, G.D., Zoledziewska, M., Sattar, N., Binder, H., Volker, U., Waldenberger, M., Khaw, K.-T., Mcknight, B., Huang, J., Jenny, N.S., Holliday, E.G., Qi, L., Mcevoy, M.G., Becker, D.M., Starr, J.M., Sarin, A.-P., Hysi, P.G., Hernandez, D.G., Jhun, M.A., Campbell, H., Hamsten, A., Sarin, F., Mcardle, W.L., Eline Slagboom, P., Zeller, T., Koenig, W., Psaty, B., Haritunians, T., Liu, J., Palotie, A., Uitterlinden, A.G., Stott, D.J., Hofman, A., Franco, O.H., Polasek, O., Rudan, I., Morange, P.-E., Wilson, J.F., Kardia, S.L.R., Ferrucci, L., Spector, T.D., Eriksson, J.G., Hansen, T., Deary, I.J., Becker, L.C., Scott, R.J., Mitchell, P., Marz, W., Wareham, N.J., Peters, A., Greinacher, A., Wild, P.S., Wouter Jukema, J., Boomsma, D.I., Hayward, C., Cucca, F., Tracy, R., Watkins, H., Reiner, A.P., Folsom, A.R., Ridker, P.M., O'Donnell, C.J., Smith, N.L., Strachan, D.P. and Dehghan, A. (2016) A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human Molecular Genetics, 25 2: 358-370. doi:10.1093/hmg/ddv454


Author De Vries, P.S.
Chasman, D.I.
Sabater-Lleal, M.
Chen, M.-H.
Huffman, J.E.
Steri, M.
Tang, W.
Teumer, A.
Marioni, R.E.
Grossmann, V.
Hottenga, J.J.
Trompet, S.
Muller-Nurasyid, M.
Zhao, J.H.
Brody, J.A.
Kleber, M.E.
Guo, X.
Wang, J.J.
Auer, P.L.
Attia, J.R.
Yanek, L.R.
Ahluwalia, T.S.
Lahti, J.
Venturini, C.
Tanaka, T.
Bielak, L.F.
Joshi, P.K.
Rocanin-Arjo, A.
Kolcic, I.
Navarro, P.
Rose, L.M.
Oldmeadow, C.
Riess, H.
Mazur, J.
Basu, S.
Goel, A.
Yang, Q.
Ghanbari, M.
Gonnekewillemsen
Rumley, A.
Fiorillo, E.
De Craen, A.J.M.
Grotevendt, A.
Scott, R.
Taylor, K.D.
Delgado, G.E.
Yao, J.
Kifley, A.
Kooperberg, C.
Qayyum, R.
Lopez, L.
Berentzen, T.L.
Raikkonen, K.
Massimomangino
Bandinelli, S.
Peyser, P.A.
Wild, S.
Tregouet, D.-A.
Wright, A.F.
Marten, J.
Zemunik, T.
Morrison, A.C.
Sennblad, B.
Tofler, G.
De Maat, M.P.M.
De Geus, E.J.C.
Lowe, G.D.
Zoledziewska, M.
Sattar, N.
Binder, H.
Volker, U.
Waldenberger, M.
Khaw, K.-T.
Mcknight, B.
Huang, J.
Jenny, N.S.
Holliday, E.G.
Qi, L.
Mcevoy, M.G.
Becker, D.M.
Starr, J.M.
Sarin, A.-P.
Hysi, P.G.
Hernandez, D.G.
Jhun, M.A.
Campbell, H.
Hamsten, A.
Sarin, F.
Mcardle, W.L.
Eline Slagboom, P.
Zeller, T.
Koenig, W.
Psaty, B.
Haritunians, T.
Liu, J.
Palotie, A.
Uitterlinden, A.G.
Stott, D.J.
Hofman, A.
Franco, O.H.
Polasek, O.
Rudan, I.
Morange, P.-E.
Wilson, J.F.
Kardia, S.L.R.
Ferrucci, L.
Spector, T.D.
Eriksson, J.G.
Hansen, T.
Deary, I.J.
Becker, L.C.
Scott, R.J.
Mitchell, P.
Marz, W.
Wareham, N.J.
Peters, A.
Greinacher, A.
Wild, P.S.
Wouter Jukema, J.
Boomsma, D.I.
Hayward, C.
Cucca, F.
Tracy, R.
Watkins, H.
Reiner, A.P.
Folsom, A.R.
Ridker, P.M.
O'Donnell, C.J.
Smith, N.L.
Strachan, D.P.
Dehghan, A.
Title A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Journal name Human Molecular Genetics   Check publisher's open access policy
ISSN 1460-2083
0964-6906
Publication date 2016-01
Year available 2015
Sub-type Article (original research)
DOI 10.1093/hmg/ddv454
Open Access Status Not Open Access
Volume 25
Issue 2
Start page 358
End page 370
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2016
Language eng
Formatted abstract
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2016 Collection
 
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