Brain lesion correlates of fatigue in individuals with traumatic brain injury

Schonberger, Michael, Reutens, David, Beare, Richard, O'Sullivan, Richard, Rajaratnam, Shantha M. W. and Ponsford, Jennie (2016) Brain lesion correlates of fatigue in individuals with traumatic brain injury. Neuropsychological Rehabilitation, 1-15. doi:10.1080/09602011.2016.1154875


Author Schonberger, Michael
Reutens, David
Beare, Richard
O'Sullivan, Richard
Rajaratnam, Shantha M. W.
Ponsford, Jennie
Title Brain lesion correlates of fatigue in individuals with traumatic brain injury
Journal name Neuropsychological Rehabilitation   Check publisher's open access policy
ISSN 1464-0694
0960-2011
Publication date 2016-03-09
Year available 2016
Sub-type Article (original research)
DOI 10.1080/09602011.2016.1154875
Open Access Status Not yet assessed
Start page 1
End page 15
Total pages 15
Place of publication Abingdon, Oxon, United Kingdom
Publisher Routledge
Collection year 2017
Language eng
Formatted abstract
The purpose of this study was to investigate the neurological correlates of both subjective fatigue as well as objective fatigability in individuals with traumatic brain injury (TBI). The study has a cross-sectional design. Participants (N = 53) with TBI (77% male, mean age at injury 38 years, mean time since injury 1.8 years) underwent a structural magnetic resonance imaging (MRI) scan and completed the Fatigue Severity Scale (FSS), while a subsample (N = 36) was also tested with a vigilance task. While subjective fatigue (FSS) was not related to measures of brain lesions, multilevel analyses showed that a change in the participants’ decision time was significantly predicted by grey matter (GM) lesions in the right frontal lobe. The time-dependent development of the participants’ error rate was predicted by total brain white matter (WM) lesion volumes, as well as right temporal GM and WM lesion volumes. These findings could be explained by decreased functional connectivity of attentional networks, which results in accelerated exhaustion during cognitive task performance. The disparate nature of objectively measurable fatigability on the one hand and the subjective experience of fatigue on the other needs further investigation.
Keyword Fatigability
Fatigue
Magnetic resonance imaging
Traumatic brain injury
Vigilance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Centre for Advanced Imaging Publications
 
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