Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration

Tsadok, Yossi, Friedman, Zvi, Haluska, Brian A., Hoffmann, Rainer and Adam, Dan (2016) Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration. Magnetic Resonance Imaging, 34 4: 381-390. doi:10.1016/j.mri.2015.12.035


Author Tsadok, Yossi
Friedman, Zvi
Haluska, Brian A.
Hoffmann, Rainer
Adam, Dan
Title Myocardial strain assessment by cine cardiac magnetic resonance imaging using non-rigid registration
Journal name Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1873-5894
0730-725X
Publication date 2016-05-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.mri.2015.12.035
Open Access Status Not Open Access
Volume 34
Issue 4
Start page 381
End page 390
Total pages 10
Place of publication Philadelphia, PA United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Aims

To evaluate a novel post-processing method for assessment of longitudinal mid-myocardial strain in standard cine cardiac magnetic resonance (CMR) imaging sequences.

Methods and results

Cine CMR imaging and tagged cardiac magnetic resonance imaging (TMRI) were performed in 15 patients with acute myocardial infarction (AMI) and 15 healthy volunteers served as control group. A second group of 37 post-AMI patients underwent both cine CMR and late gadolinium enhancement (LGE) CMR exams. Speckle tracking echocardiography (STE) was performed in 36 of these patients. Cine CMR, TMRI and STE were analyzed to obtain longitudinal strain. LGE-CMR datasets were analyzed to evaluate scar extent. Comparison of peak systolic strain (PSS) measured from CMR and TMRI yielded a strong correlation (r = 0.86, p < 0.001). PSS measured from CMR and STE correlated well (r = 0.75, p < 0.001). A cutoff longitudinal PSS value of − 13.14% differentiated non-infarction from any infarcted myocardium, with a sensitivity of 93% and a specificity of 89% (area under curve (AUC) 0.95). PSS value of − 9.39% differentiated non-transmural from transmural infarcted myocardium, with a sensitivity of 75% and a specificity of 67% (AUC 0.78).

Conclusion

The present study showed a novel off-line post-processing method for segmental longitudinal strain analysis in mid-myocardium layer based on cine CMR data. The method was found to be highly correlated with strain measurements obtained by TMRI and STE. This tool allows accurate discrimination between different transmurality states of myocardial infarction.
Keyword Cardiac magnetic resonance
Strain analysis
Tagged magnetic resonance imaging
Speckle tracking echocardiography
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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