Efficient drug delivery using SiO2-layered double hydroxide nanocomposites

Li, Li, Gu, Zi, Gu, Wenyi, Liu, Jian and Xu, Zhi Ping (2016) Efficient drug delivery using SiO2-layered double hydroxide nanocomposites. Journal of Colloid and Interface Science, 470 47-55. doi:10.1016/j.jcis.2016.02.042


Author Li, Li
Gu, Zi
Gu, Wenyi
Liu, Jian
Xu, Zhi Ping
Title Efficient drug delivery using SiO2-layered double hydroxide nanocomposites
Formatted title
Efficient drug delivery using SiO2-layered double hydroxide nanocomposites
Journal name Journal of Colloid and Interface Science   Check publisher's open access policy
ISSN 1095-7103
0021-9797
Publication date 2016-05-15
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jcis.2016.02.042
Open Access Status Not Open Access
Volume 470
Start page 47
End page 55
Total pages 9
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Formatted abstract
MgAl-layered double hydroxide (MgAl-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10-15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth.
Keyword Drug delivery
Functionalization
Layered double hydroxide (LDH)
Nanocomposites
Self-assembly
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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