The developmental origins of renal dysfunction

Cuffe, James S. M., Walton, Sarah L. and Moritz, Karen M. (2016). The developmental origins of renal dysfunction. In Cheryl S. Rosenfeld (Ed.), The epigenome and developmental origins of health and disease (pp. 291-314) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-801383-0.00015-3

Author Cuffe, James S. M.
Walton, Sarah L.
Moritz, Karen M.
Title of chapter The developmental origins of renal dysfunction
Title of book The epigenome and developmental origins of health and disease
Place of Publication London, United Kingdom
Publisher Academic Press
Publication Year 2016
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-801383-0.00015-3
Open Access Status Not yet assessed
ISBN 9780128013830
Editor Cheryl S. Rosenfeld
Chapter number 15
Start page 291
End page 314
Total pages 24
Total chapters 26
Collection year 2017
Language eng
Abstract/Summary Impairments in renal function can contribute to multiple disorders including chronic kidney disease and hypertension. Although adult onset renal dysfunction may in part be attributable to lifestyle choices or other morbidities, such as diabetes, the “developmental origins of health and disease” hypothesis has suggested that impaired renal development may predispose offspring to later renal disease. This chapter will detail the epidemiological and experimental evidence highlighting the importance of impaired kidney development in the programming of adult renal dysfunction and associated diseases. Emphasis will be placed on links between a low nephron endowment and increased risk of high blood pressure and chronic kidney disease. We will also examine the molecular and epigenetic pathways affected by maternal perturbations that may give rise to a reduction in nephron number and subsequent alterations in renal function in adult life.
Keyword Renin-angiotensin system
Reduces nephron number
Chronic kidney disease
Low birth weight
Intrauterine growth restriction
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
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School of Biomedical Sciences Publications
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