A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis.

Noor Harun, Sabariah, Wainwright, Claire, Klein, Kerenaftali and Hennig, Stefanie (2016) A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis.. Paediatric Respiratory Reviews, 20 55-66. doi:10.1016/j.prrv.2016.03.002

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Author Noor Harun, Sabariah
Wainwright, Claire
Klein, Kerenaftali
Hennig, Stefanie
Title A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis.
Journal name Paediatric Respiratory Reviews   Check publisher's open access policy
ISSN 1526-0542
1526-0550
Publication date 2016-02-28
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.prrv.2016.03.002
Open Access Status Not Open Access
Volume 20
Start page 55
End page 66
Total pages 12
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
A systematic review was performed (i) to describe the reported overall rate of progression of CF lung disease quantified as FEV1%predicted decline with age, (ii) to summarise identified influencing risk factors and (iii) to review methods used to analyse CF lung disease progression data. A search of publications providing FEV1%predicted values over age was conducted in PUBMED and EMBASE. Baseline and rate of FEV1%predicted decline were summarised overall and by identified risk factors. Thirty-nine studies were included and reported variable linear rates of lung function decline in patients with CF. The overall weighted mean FEV1%predicted over age was graphically summarised and showed a nonlinear, time-variant decline of lung function. Compared to their peers, Pseudomonas aeruginosa infection and pancreatic insufficiency were most commonly associated with lower baseline and more rapid FEV1%predicted declines respectively. Considering nonlinear models and drop-out in lung disease progression, analysis is lacking and more studies are warranted.
Keyword Cystic fibrosis
Lung function
Disease progression
Risk factors
Nonlinear decline
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Pharmacy Publications
 
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Created: Thu, 24 Mar 2016, 15:40:27 EST by Dr Stefanie Hennig on behalf of School of Pharmacy