TCDD exposure-response analysis and risk assessment

Cheng, Hong, Aylward, Lesa, Beall, Colleen, Starr, Thomas B., Brunet, Robert C., Carrier, Gaetan and Delzell, Elizabeth (2006) TCDD exposure-response analysis and risk assessment. Risk Analysis, 26 4: 1059-1071. doi:10.1111/j.1539-6924.2006.00800.x


Author Cheng, Hong
Aylward, Lesa
Beall, Colleen
Starr, Thomas B.
Brunet, Robert C.
Carrier, Gaetan
Delzell, Elizabeth
Title TCDD exposure-response analysis and risk assessment
Journal name Risk Analysis   Check publisher's open access policy
ISSN 0272-4332
1539-6924
Publication date 2006-08
Sub-type Article (original research)
DOI 10.1111/j.1539-6924.2006.00800.x
Open Access Status Not yet assessed
Volume 26
Issue 4
Start page 1059
End page 1071
Total pages 13
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
We examined the relation between cancer mortality and time-dependent cumulative exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) estimated from a concentration- and age-dependent kinetic model of elimination, and we estimated incremental cancer risks at age 75. Data from the National Institute for Occupational Safety and Health study of 3,538 workers with occupational exposure to TCDD were analyzed using standardized mortality ratios and Cox regression procedures. Analyses adjusted for potential confounding by age, year of birth, and race and considered exposure lag periods of 0, 10, or 15 years. Other potential confounders including smoking and other occupational exposures were evaluated indirectly. To explore the influence of extreme values of cumulative TCDD ppt-years, we restricted the analysis to observations with exposure below the 95th percentile or used logarithmic (ln) transformed exposure values. We applied penalized smoothing splines to examine variation in the exposure-response relation across the exposure range. TCDD was not statistically significantly associated with cancer mortality using the full data set, regardless of the lag period. When we restricted the analysis to observations with exposure below the 95th percentile, TCDD was associated positively with cancer mortality, particularly when a 15-year lag was applied (untransformed exposure data: regression coefficient (β̂) = 3.3 × 10-6, standard error (s.e.) = 1.4 × 10-6, p < 0.05; ln-transformed exposure data: β̂ = 8.1 × 10-2, s.e. = 2.9 × 10-2, p < 0.05). The estimated incremental lifetime risk of mortality at age 75 from all cancerswas about 6 to more than 10 times lower than previous estimates derived from this cohortusing exposure models that did not consider the age and concentration dependence of TCDD elimination.
Keyword 2,3,7,8-tetrachlorodibenzo-p-dioxin
Cancer
Dioxin
TCDD
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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