Hepatic p450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans

Moore, Jeremy N., Newsted, John L., Hecker, Markus, Zwiernik, Matthew J., Fitzgerald, Scott D., Kay, Denise P., Zhang, Xiaowei, Higley, Eric B., Aylward, Lesa L., Beckett, Kerrie J., Budinsky, Robert A., Bursian, Steven J. and Giesy, John P. (2009) Hepatic p450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans. Archives of Environmental Contamination and Toxicology, 57 2: 416-425. doi:10.1007/s00244-008-9241-3


Author Moore, Jeremy N.
Newsted, John L.
Hecker, Markus
Zwiernik, Matthew J.
Fitzgerald, Scott D.
Kay, Denise P.
Zhang, Xiaowei
Higley, Eric B.
Aylward, Lesa L.
Beckett, Kerrie J.
Budinsky, Robert A.
Bursian, Steven J.
Giesy, John P.
Title Hepatic p450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans
Formatted title
Hepatic p450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans
Journal name Archives of Environmental Contamination and Toxicology   Check publisher's open access policy
ISSN 0090-4341
1432-0703
Publication date 2009-08
Sub-type Article (original research)
DOI 10.1007/s00244-008-9241-3
Open Access Status DOI
Volume 57
Issue 2
Start page 416
End page 425
Total pages 10
Place of publication New York, NY, United States
Publisher Springer New York LLC
Language eng
Formatted abstract
Dose- and time-dependent effects of environmentally relevant concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TEQ) of 2,3,7,8-tetrachlorodibenzofuran (TCDF), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), or a mixture of these two congeners on hepatic P450 enzyme activity and tissue morphology, including jaw histology, of adult ranch mink were determined under controlled conditions. Adult female ranch mink were fed either TCDF (0.98, 3.8, or 20 ng TEQTCDF/kg bw/day) or PeCDF (0.62, 2.2, or 9.5 ng TEQPeCDF/kg bw/day), or a mixture of TCDF and PeCDF (4.1 ng TEQTCDF/kg bw/day and 2.8 ng TEQPeCDF/kg bw/day, respectively) for 180 days. Doses used in this study were approximately eight times greater than those reported in a parallel field study. Activities of the cytochrome P450 1A enzymes, ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-deethylase (MROD) were significantly greater in livers of mink exposed to TCDF, PeCDF, and a mixture of the two congeners; however, there were no significant histological or morphological effects observed. It was determined that EROD and MROD activity can be used as sensitive biomarkers of exposure to PeCDF and TCDF in adult female mink; however, under the conditions of this study, the response of EROD/MROD induction occurred at doses that were less than those required to cause histological or morphological changes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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