Biomonitoring equivalents for di-isononyl phthalate (DINP)

Hays, Sean M., Aylward, Lesa L., Kirman, Christopher R., Krishnan, Kannan and Nong, Andy (2011) Biomonitoring equivalents for di-isononyl phthalate (DINP). Regulatory Toxicology and Pharmacology, 60 2: 181-188. doi:10.1016/j.yrtph.2011.03.013


Author Hays, Sean M.
Aylward, Lesa L.
Kirman, Christopher R.
Krishnan, Kannan
Nong, Andy
Title Biomonitoring equivalents for di-isononyl phthalate (DINP)
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 0273-2300
1096-0295
Publication date 2011-07
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2011.03.013
Open Access Status Not yet assessed
Volume 60
Issue 2
Start page 181
End page 188
Total pages 8
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline such as a reference dose (RfD) or tolerable daily intake (TDI). BE values can be used as a screening tool for the evaluation of population-based biomonitoring data in the context of existing risk assessments. This study reviews available health based risk assessments and exposure guidance values for di-isononyl phthalate (DINP) from Health Canada, the United States Consumer Product Safety Commission (US CPSC), and the European Food Safety Authority (EFSA). Controlled dosing data reporting the urinary excretion fractions of major DINP metabolites following administration of labeled DINP are reviewed, and BE values corresponding to the available exposure guidance values are derived assuming chronic, steady-state intake and excretion at those exposure values. The BE values range from 1500 to 3600 μg/L (1900-4600 μg/g creatinine) based on the sum of three oxidative metabolites. Sources of uncertainty relating to both the basis for the BE values and their use in evaluation of biomonitoring data, including the transience of the biomarkers relative to exposure frequency, are discussed. The BE values derived here can be used as screening tools for evaluation of population biomonitoring data for DINP in the context of existing risk assessments and can assist in prioritization of the potential need for additional risk assessment efforts for DINP relative to other chemicals.
Keyword Biomonitoring equivalents
Di-isononyl phthalate
DINP
Risk assessment
Toxicokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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