Evaluation of biomonitoring data from the CDC national exposure report in a risk assessment context: perspectives across chemicals

Aylward, Lesa L., Kirman, Christopher R., Schoeny, Rita, Portier, Christopher J. and Hays, Sean M. (2013) Evaluation of biomonitoring data from the CDC national exposure report in a risk assessment context: perspectives across chemicals. Environmental Health Perspectives, 121 3: 287-294. doi:10.1289/ehp.1205740


Author Aylward, Lesa L.
Kirman, Christopher R.
Schoeny, Rita
Portier, Christopher J.
Hays, Sean M.
Title Evaluation of biomonitoring data from the CDC national exposure report in a risk assessment context: perspectives across chemicals
Journal name Environmental Health Perspectives   Check publisher's open access policy
ISSN 0091-6765
1552-9924
Publication date 2013-03-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1289/ehp.1205740
Open Access Status DOI
Volume 121
Issue 3
Start page 287
End page 294
Total pages 8
Place of publication Research Triangle Park, NC, United States
Publisher U.S. Department of Health and Human Services * National Institute of Environmental Health Sciences
Language eng
Formatted abstract
Background: Biomonitoring data reported in the National Report on Human Exposure to Environmental Chemicals [NER; Centers for Disease Control and Prevention (2012)] provide information on the presence and concentrations of > 400 chemicals in human blood and urine. Biomonitoring Equivalents (BEs) and other risk assessment-based values now allow interpretation of these biomonitoring data in a public health risk context.

Objectives: We compared the measured biomarker concentrations in the NER with BEs and similar risk assessment values to provide an across-chemical risk assessment perspective on the measured levels for approximately 130 analytes in the NER.

Methods: We identified available risk assessment-based biomarker screening values, including BEs and Human Biomonitoring-I (HBM-I) values from the German Human Biomonitoring Commission. Geometric mean and 95th percentile population biomarker concentrations from the NER were compared to the available screening values to generate chemical-specific hazard quotients (HQs) or cancer risk estimates.

Conclusions: Most analytes in the NER show HQ values of < 1; however, some (including acrylamide, dioxin-like chemicals, benzene, xylene, several metals, di-2(ethylhexyl)phthalate, and some legacy organochlorine pesticides) approach or exceed HQ values of 1 or cancer risks of > 1 × 10-4 at the geometric mean or 95th percentile, suggesting exposure levels may exceed published human health benchmarks. This analysis provides for the first time a means for examining population biomonitoring data for multiple environmental chemicals in the context of the risk assessments for those chemicals. The results of these comparisons can be used to focus more detailed chemical-specific examination of the data and inform priorities for chemical risk management and research.
Keyword Biomonitoring
Biomonitoring equivalents
Blood
Cancer risk
CDC national exposure report
Hazard quotient
NHANES
Risk assessment
Urine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Pharmacy Publications
 
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