Sources of variability in biomarker concentrations

Aylward, Lesa L., Hays, Sean M., Smolders, Roel, Koch, Holger M., Cocker, John, Jones, Kate, Warren, Nicholas, Levy, Len and Bevan, Ruth (2014) Sources of variability in biomarker concentrations. Journal of Toxicology and Environmental Health. Part B: Critical Reviews, 17 1: 45-61. doi:10.1080/10937404.2013.864250

Author Aylward, Lesa L.
Hays, Sean M.
Smolders, Roel
Koch, Holger M.
Cocker, John
Jones, Kate
Warren, Nicholas
Levy, Len
Bevan, Ruth
Title Sources of variability in biomarker concentrations
Journal name Journal of Toxicology and Environmental Health. Part B: Critical Reviews   Check publisher's open access policy
ISSN 1521-6950
Publication date 2014-01-02
Year available 2014
Sub-type Article (original research)
DOI 10.1080/10937404.2013.864250
Open Access Status Not yet assessed
Volume 17
Issue 1
Start page 45
End page 61
Total pages 17
Place of publication New York, NY, United States
Publisher Taylor & Francis
Language eng
Abstract Human biomonitoring has become a primary tool for chemical exposure characterization in a wide variety of contexts: population monitoring and characterization at a national level, assessment and description of cohort exposures, and individual exposure assessments in the context of epidemiological research into potential adverse health effects of chemical exposures. The accurate use of biomonitoring as an exposure characterization tool requires understanding of factors, apart from external exposure level, that influence variation in biomarker concentrations. This review provides an overview of factors that might influence inter- and intraindividual variation in biomarker concentrations apart from external exposure magnitude. These factors include characteristics of the specific chemical of interest, characteristics of the likely route(s) and frequency of exposure, and physiological characteristics of the biomonitoring matrix (typically, blood or urine). Intraindividual variation in biomarker concentrations may be markedly affected by the relationship between the elimination half-life and the intervals between exposure events, as well as by variation in characteristics of the biomonitored media such as blood lipid content or urinary flow rate. Variation across individuals may occur due to differences in time of sampling relative to exposure events, physiological differences influencing urinary flow or creatinine excretion rates or blood characteristics, and interindividual differences in metabolic rate or other factors influencing the absorption or excretion rate of a compound. Awareness of these factors can assist researchers in improving the design and interpretation of biomonitoring studies.
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Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
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