Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: application of chemical-specific screening criteria

Kirman, Christopher R., Aylward, Lesa L., Blount, Ben C., Pyatt, David W. and Hays, Sean M. (2012) Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: application of chemical-specific screening criteria. Journal of Exposure Science and Environmental Epidemiology, 22 1: 24-34. doi:10.1038/jes.2011.37


Author Kirman, Christopher R.
Aylward, Lesa L.
Blount, Ben C.
Pyatt, David W.
Hays, Sean M.
Title Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: application of chemical-specific screening criteria
Journal name Journal of Exposure Science and Environmental Epidemiology   Check publisher's open access policy
ISSN 1559-0631
1559-064X
Publication date 2012
Year available 2011
Sub-type Article (original research)
DOI 10.1038/jes.2011.37
Open Access Status Not yet assessed
Volume 22
Issue 1
Start page 24
End page 34
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Available biomonitoring data for volatile organic chemicals (VOCs) in blood from the National Health and Nutrition Examination Survey (NHANES) (2003-2004) (CDC, 2009) were compared with recently derived screening biomonitoring equivalent (BE) values (Aylward et al., 2010). A BE is defined as the estimated concentration or range of concentrations of a chemical or its metabolites in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guidance value. Blood concentrations of VOCs from the NHANES data set were compared with predicted screening BE values based upon a hazard quotient (HQ) for individual chemicals, and a hazard index (HI) approach for combined exposures. HI values for detected chemicals were generally at or below a value of 1, suggesting that the potential for deleterious effects is low. However, smoking was an important determinant of HI and HQ values. Detected levels of benzene in non-smokers were within the range of BE values corresponding to a 1 × 10-6 -1 × 10-4 range for upper-bound cancer risk; in smokers, levels of benzene were at the upper end of or exceeded this range. For VOCs that were not detected in the NHANES sampling, analytical detection limits were generally sufficiently sensitive to detect concentrations consistent with existing non-cancer and cancer risk-based exposure guidance values. Interpretations of measured blood concentrations of VOCs must be made with caution due to the substantial within-individual, within-day fluctuations in levels expected due to the rapid elimination of VOCs.
Keyword Biomonitoring
Biomonitoring equivalents
Risk assessment
VOCs
Volatile organic compounds
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 24 Mar 2016, 11:25:34 EST by System User on behalf of Learning and Research Services (UQ Library)