Screening of population level biomonitoring data from the Canadian Health Measures Survey in a risk-based context

St-Amand, Annie, Werry, Kate, Aylward, Lesa L., Hays, Sean M. and Nong, Andy (2014) Screening of population level biomonitoring data from the Canadian Health Measures Survey in a risk-based context. Toxicology Letters, 231 2: 126-134. doi:10.1016/j.toxlet.2014.10.019


Author St-Amand, Annie
Werry, Kate
Aylward, Lesa L.
Hays, Sean M.
Nong, Andy
Title Screening of population level biomonitoring data from the Canadian Health Measures Survey in a risk-based context
Journal name Toxicology Letters   Check publisher's open access policy
ISSN 1879-3169
0378-4274
Publication date 2014-12-01
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.toxlet.2014.10.019
Open Access Status Not yet assessed
Volume 231
Issue 2
Start page 126
End page 134
Total pages 9
Place of publication Shannon, Clare, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Since 2007, the Canadian Health Measures Survey (CHMS) has been collecting biomonitoring data from the general Canadian population and has provided, to date, nationally representative concentrations for hundreds of environmental biomarkers in blood or urine. Biomonitoring Equivalents (BEs) have been developed as tools to help interpret biomonitoring data in a health risk context at a population level. In this paper, BEs are used to relate biomonitoring data from the CHMS (2007–2011) to existing exposure guidance values developed by Health Canada and other government agencies. Chemical-specific hazard quotients (HQs) and/or cancer risk estimates are calculated using existing BEs corresponding to environmental chemicals analyzed in the CHMS.

For the majority of environmental chemicals, calculated HQ values are less than 1 indicating exposure is below published exposure guidance values. Individual biomonitoring data for two biomarkers of metal exposure (inorganic arsenic and cadmium) resulted in HQ values exceeding 1 suggesting that exposure may be above existing guidance values for a portion of the population, at least intermittently. This type of analysis may be used by researchers, risk assessors, and risk managers in prioritization efforts.
Keyword Biomonitoring
Biomonitoring equivalents
Blood
CHMS
Hazard quotient
Risk assessment
Urine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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