Advancing exposure characterization for chemical evaluation and risk assessment

Hubal, Elaine A. Cohen, Richard, Ann, Aylward, Lesa, Edwards, Steve, Gallagher, Jane, Goldsmith, Michael-Rock, Isukapalli, Sastry, Tornero-Velez, Rogelio, Weber, Eric and Kavlock, Robert (2010) Advancing exposure characterization for chemical evaluation and risk assessment. Journal of Toxicology and Environmental Health. Part B: Critical Reviews, 13 2-4: 299-313. doi:10.1080/10937404.2010.483947


Author Hubal, Elaine A. Cohen
Richard, Ann
Aylward, Lesa
Edwards, Steve
Gallagher, Jane
Goldsmith, Michael-Rock
Isukapalli, Sastry
Tornero-Velez, Rogelio
Weber, Eric
Kavlock, Robert
Title Advancing exposure characterization for chemical evaluation and risk assessment
Journal name Journal of Toxicology and Environmental Health. Part B: Critical Reviews   Check publisher's open access policy
ISSN 1093-7404
1521-6950
Publication date 2010
Sub-type Article (original research)
DOI 10.1080/10937404.2010.483947
Open Access Status Not yet assessed
Volume 13
Issue 2-4
Start page 299
End page 313
Total pages 15
Place of publication New York, NY, United States
Publisher Taylor & Francis
Language eng
Formatted abstract
A new generation of scientific tools has emerged to rapidly measure signals from cells, tissues, and organisms following exposure to chemicals. High-visibility efforts to apply these tools for efficient toxicity testing raise important research questions in exposure science. As vast quantities of data from high-throughput screening (HTS) in vitro toxicity assays become available, this new toxicity information must be translated to assess potential risks to human health from environmental exposures. Exposure information is required to link information on potential toxicity of environmental contaminants to real-world health outcomes. In the immediate term, tools are required to characterize and classify thousands of environmental chemicals in a rapid and efficient manner to prioritize testing and assess potential for risk to human health. Rapid risk assessment requires prioritization based on both hazard and exposure dimensions of the problem. To address these immediate needs within the context of longer term objectives for chemical evaluation and risk management, a translation framework is presented for incorporating toxicity and exposure information to inform public health decisions at both the individual and population levels. Examples of required exposure science contributions are presented with a focus on early advances in tools for modeling important links across the source-to-outcome paradigm. ExpoCast, a new U.S. Environmental Protection Agency (EPA) program aimed at developing novel approaches and metrics to screen and evaluate chemicals based on the potential for biologically relevant human exposures is introduced. The goal of ExpoCast is to advance characterization of exposure required to translate findings in computational toxicology to information that can be directly used to support exposure and risk assessment for decision making and improved public health.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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