Rapid communication: background concentrations of dioxins, furans, and PCBs in Sprague-Dawley rats and juvenile swine

Ruby, Michael V., Casteel, Stan W., Evans, Timothy J., Fehling, Kurt A., Paustenbach, Dennis J., Budinsky, Robert A., Giesy, John P., Aylward, Lesa L. and Landenberger, Bryce D. (2004) Rapid communication: background concentrations of dioxins, furans, and PCBs in Sprague-Dawley rats and juvenile swine. Journal of Toxicology and Environmental Health - Part A, 67 11: 845-850. doi:10.1080/15287390490441265


Author Ruby, Michael V.
Casteel, Stan W.
Evans, Timothy J.
Fehling, Kurt A.
Paustenbach, Dennis J.
Budinsky, Robert A.
Giesy, John P.
Aylward, Lesa L.
Landenberger, Bryce D.
Title Rapid communication: background concentrations of dioxins, furans, and PCBs in Sprague-Dawley rats and juvenile swine
Journal name Journal of Toxicology and Environmental Health - Part A   Check publisher's open access policy
ISSN 1528-7394
1087-2620
Publication date 2004-06-11
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1080/15287390490441265
Open Access Status Not yet assessed
Volume 67
Issue 11
Start page 845
End page 850
Total pages 6
Place of publication New York, NY, United States
Publisher Taylor & Francis
Language eng
Formatted abstract
In preparation for a study of the relative oral bioavailability of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in soils (typically containing less than 1 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin [TCDD] toxic equivalents [TEQ]), the background concentrations of PCDD/ Fs and selected polychlorinated biphenyls (PCBs) were measured in liver and adipose tissue from female Sprague-Dawley rats and juvenile swine after 30 d of ingesting laboratory chow. The measured concentrations of TCDD and other PCDD/Fs in rat livers were severalfold less than previously reported in the literature for control (unexposed) laboratory rodents. The concentrations of PCDD/Fs and selected PCBs in livers of swine were three- to fourfold lower than those reported for rats. The lower concentrations found in this study compared to previous findings may be due to inadvertent laboratory contamination in previous studies or to declining levels of PCDD/Fs in laboratory feed, which parallel the declines in emissions, general environmental levels, and human food and tissue levels of PCDD/Fs.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: National Research Centre for Environmental Toxicology Publications
 
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