Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels

Aylward, Lesa L. and Hays, Sean M. (2002) Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels. Journal of Exposure Analysis and Environmental Epidemiology, 12 5: 319-328. doi:10.1038/sj.jea.7500233


Author Aylward, Lesa L.
Hays, Sean M.
Title Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels
Journal name Journal of Exposure Analysis and Environmental Epidemiology   Check publisher's open access policy
ISSN 1053-4245
1559-064X
Publication date 2002
Sub-type Article (original research)
DOI 10.1038/sj.jea.7500233
Open Access Status Not yet assessed
Volume 12
Issue 5
Start page 319
End page 328
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
Data on lipid levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the general population in the United States, Canada, Germany, and France over the past 30 years were compiled from the literature. Mean lipid levels of TCDD exhibited a steady decrease by nearly a factor of 10 over this time period, with lipid-adjusted TCDD levels in 2000 about 2 parts per trillion (ppt). Pharmacokinetic modeling using a one-compartment model indicated that absorbed intake levels of TCDD must have decreased by more than 95% from levels in 1972 to result in the observed decrease in human lipid levels, with the bulk of this decrease occurring before 1980. Based on this modeling and the pharmacokinetic properties of TCDD in humans, we conclude that mean levels of TCDD in the general population are likely to decrease further over the next 15 years, to between 0.5 and 1 ppt, even if intake levels do not decrease further. Fewer data over a shorter time period are available for other dioxin and furan congeners in human lipid, but these data indicate substantial decreases as well, with general population TEQ lipid levels currently at least fourfold lower than in 1970 and still decreasing. Food sampling data are limited, but support these trends.
Keyword Human exposure
TCDD
Temporal trends
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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