Biomonitoring Equivalents for 2,2',4,4',5-pentabromodiphenylether (PBDE-99)

Krishnan, Kannan, Adamou, Therese, Aylward, Lesa L., Hays, Sean M., Kirman, Christopher R. and Nong, Andy (2011) Biomonitoring Equivalents for 2,2',4,4',5-pentabromodiphenylether (PBDE-99). Regulatory Toxicology and Pharmacology, 60 2: 165-171. doi:10.1016/j.yrtph.2011.03.011


Author Krishnan, Kannan
Adamou, Therese
Aylward, Lesa L.
Hays, Sean M.
Kirman, Christopher R.
Nong, Andy
Title Biomonitoring Equivalents for 2,2',4,4',5-pentabromodiphenylether (PBDE-99)
Journal name Regulatory Toxicology and Pharmacology   Check publisher's open access policy
ISSN 0273-2300
1096-0295
Publication date 2011-07
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.yrtph.2011.03.011
Open Access Status Not yet assessed
Volume 60
Issue 2
Start page 165
End page 171
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
Biomonitoring Equivalents (BEs) are defined as the concentration or range of concentrations of a chemical or its metabolite in a biological medium (blood, urine, or other medium) that is consistent with an existing health-based exposure guideline such as a reference dose (RfD) or tolerable daily intake (TDI). BE values can be used as a screening tool for the evaluation of population-based biomonitoring data in the context of existing risk assessments. This study reviews health based risk assessments and exposure guidance values for 2,2',4,4',5-pentabromodiphenylether (PBDE-99) from Health Canada and the United States Environmental Protection Agency (US EPA). Toxicokinetic data from laboratory animals and humans are reviewed. A BE value corresponding to the US EPA RfD is derived here for PBDE-99 based on the assumption of chronic steady-state exposure, distribution into body lipids, and a previously-estimated first-order half-life of elimination of 1040days. The steady-state lipid-adjusted BERfD is 520ng/g lipid. Sources of uncertainty relating to the underlying toxicokinetic and toxicologic database for PBDE-99 and the simultaneous exposure to multiple PBDE congeners are discussed. The BERfD value may be used as a screening tool for evaluation of population biomonitoring data for PBDE-99 in the context of the existing US EPA risk assessment and can assist in prioritization of the potential need for additional risk assessment efforts for PBDE-99 relative to other chemicals.
Keyword 2,2',4,4',5-Pentabromodiphenylether
Biomonitoring Equivalents
PBDE-99
Polybrominated biphenyl ethers
Risk assessment
Toxicokinetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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