The role of interleukin-6 in malignant mesothelioma

Abdul Rahim, Siti N., Ho, Gwo Y. and Coward J.I.G. (2015) The role of interleukin-6 in malignant mesothelioma. Translational Lung Cancer Research, 4 1: 55-66. doi:10.3978/j.issn.2218-6751.2014.07.01

Author Abdul Rahim, Siti N.
Ho, Gwo Y.
Coward J.I.G.
Title The role of interleukin-6 in malignant mesothelioma
Journal name Translational Lung Cancer Research   Check publisher's open access policy
ISSN 2226-4477
Publication date 2015-02
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.3978/j.issn.2218-6751.2014.07.01
Open Access Status Not Open Access
Volume 4
Issue 1
Start page 55
End page 66
Total pages 12
Place of publication Pioneer Bioscience Publishing Company
Publisher Hong Kong
Collection year 2016
Language eng
Abstract Malignant mesothelioma (MM) still remains a dismal disease with a median overall survival between 9-12 months. During the past decade since the introduction of the multi-folate antagonist, pemetrexed, there have been no significant advances in its systemic treatment, particularly with novel therapeutics that have exhibited varying degrees of success in other solid tumours. In recent years, the pleiotropic proinflammatory cytokine, interleukin-6 (IL-6) has emerged as a mediator of pivotal processes such as cell proliferation and chemoresistance within the mesothelioma tumour microenvironment in addition to clinical symptoms commonly witnessed in this disease. This manuscript provides a brief summary on the pathophysiology and clinical management of MM, followed by the role of IL-6 in its tumourigenesis and the rationale for utilising anti-IL-6 therapeutics alongside standard chemotherapy and targeted agents in an attempt to prolong survival.
Keyword Interleukin-6 (IL-6)
Malignant mesothelioma (MM)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2016 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
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Citation counts: Scopus Citation Count Cited 3 times in Scopus Article | Citations
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Created: Thu, 24 Mar 2016, 11:09:47 EST by Julia McCabe on behalf of Mater Research Institute-UQ