Mother's smoking and complex lung function of offspring in middle age: a cohort study from childhood

Perret, Jennifer L., Walters, Haydn, Johns, David, Gurrin, Lyle, Burgess, John, Lowe, Adrian, Thompson, Bruce, Markos, James, Morrison, Stephen, Thomas, Paul, Mcdonald, Christine, Wood-Baker, Richard, Hopper, John, Svanes, Cecilie, Giles, Graham, Abramson, MIchael, Matheson, Melanie and Dharmage, Shyamali (2016) Mother's smoking and complex lung function of offspring in middle age: a cohort study from childhood. Respirology, 21 5: 911-919. doi:10.1111/resp.12750

Author Perret, Jennifer L.
Walters, Haydn
Johns, David
Gurrin, Lyle
Burgess, John
Lowe, Adrian
Thompson, Bruce
Markos, James
Morrison, Stephen
Thomas, Paul
Mcdonald, Christine
Wood-Baker, Richard
Hopper, John
Svanes, Cecilie
Giles, Graham
Abramson, MIchael
Matheson, Melanie
Dharmage, Shyamali
Title Mother's smoking and complex lung function of offspring in middle age: a cohort study from childhood
Journal name Respirology   Check publisher's open access policy
ISSN 1440-1843
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1111/resp.12750
Open Access Status Not Open Access
Volume 21
Issue 5
Start page 911
End page 919
Total pages 9
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2017
Language eng
Formatted abstract
Background and objective: Existing evidence that supports maternal smoking to be a potential risk factor for chronic obstructive pulmonary disease (COPD) for adult offspring has barely been mentioned in major guideline documents, suggesting a need for more robust and consistent data. We aimed to examine whether such early life exposure can predispose to COPD in middle age, possibly through its interaction with personal smoking.

Methods: The fifth-decade follow-up of the Tasmanian Longitudinal Health Study cohort, which was first studied in 1968 (n = 8583), included a 2004 postal survey (n = 5729 responses) and subsequent laboratory attendance (n = 1389) for comprehensive lung function testing between 2006 and 2008. Multivariable linear and logistic regression models included sampling weights.

Results: Post-bronchodilator airflow obstruction (less than fifth percentile) was detected for 9.3% (n = 123) of middle-aged offspring. Its association with heavy maternal smoking (>20 cigarettes/day) during childhood was 2.7-fold higher than for those without exposure (95% confidence interval [1.3, 5.7] P = 0.009). Maternal smoking per se approximately doubled the adverse effect of personal smoking on gas transfer factor (z-score −0.46 [−0.6 to −0.3] vs −0.25 [−0.4 to −0.1], P[interaction] = 0.048) and was paradoxically associated with reduced residual volumes for non-smokers.

Conclusions: Heavy maternal smoking during childhood appears to predispose to spirometrically defined COPD. The interplay between maternal and personal smoking on gas transfer factor suggests that early life exposure increases an individual's susceptibility to adult smoking exposure. These findings provide further evidence to suggest that maternal smoking might be a risk factor for COPD and reinforce the public health message advocating smoking abstinence.
Keyword Adult offspring
Airflow obstruction
Gas transfer factor
Maternal smoking
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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