Characterization of Th17 and FoxP3+ treg cells in paediatric psoriasis patients

Zhang, L., Li, Y., Yang, X., Wei, J., Zhou, S., Zhao, Z., Cheng, J., Duan, H., Jia, T., Lei, Q., Huang, J. and Feng, C. (2016) Characterization of Th17 and FoxP3+ treg cells in paediatric psoriasis patients. Scandinavian Journal of Immunology, 83 3: 174-180. doi:10.1111/sji.12404


Author Zhang, L.
Li, Y.
Yang, X.
Wei, J.
Zhou, S.
Zhao, Z.
Cheng, J.
Duan, H.
Jia, T.
Lei, Q.
Huang, J.
Feng, C.
Title Characterization of Th17 and FoxP3+ treg cells in paediatric psoriasis patients
Formatted title
Characterization of Th17 and FoxP3+ treg cells in paediatric psoriasis patients
Journal name Scandinavian Journal of Immunology   Check publisher's open access policy
ISSN 1365-3083
0300-9475
Publication date 2016-03-01
Year available 2016
Sub-type Article (original research)
DOI 10.1111/sji.12404
Open Access Status Not yet assessed
Volume 83
Issue 3
Start page 174
End page 180
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2017
Language eng
Formatted abstract
Psoriasis is one of the most common inflammatory skin conditions affecting both children and adults. Growing evidence indicates that T-helper 17 (Th17) cells and CD4+CD25+ regulatory T (Treg) cells play an important role in the pathogenesis of psoriasis. However, the relationship between Th17 and Treg cells and their dynamic variations in paediatric psoriasis remain unclear. In this study, we found that both Th17 and FoxP3+ Treg cells and the ratio of Th17 to Treg cell frequency in the peripheral circulation were increased in patients with paediatric psoriasis and were positively correlated with the disease severity. The function of Treg to suppress CD4+CD25- T cell proliferation and IFN-γ secretion was impaired during the onset of psoriasis. After disease remission, both the Th17 and Treg cell frequencies were decreased, and the suppressive function of the Treg cells was obviously restored. However, neither Treg cells from the disease onset nor those after remission can regulate IL-17 secretion by CD4+ T cells. These findings will further our understanding of the associations between Th17 and Treg cells in paediatric psoriasis and their influence on disease severity.
Keyword Psoriasis
Inflammatory skin disease
T-helper 17 (Th17) cells
CD4+CD25+ regulatory T (Treg) cells
Paediatric psoriasis
Disease severity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 22 Mar 2016, 01:17:14 EST by System User on behalf of Learning and Research Services (UQ Library)