Use of inhaled corticosteroids in COPD: improving efficacy

Yang, Ian A., Shaw, Janet G., Goddard, John R., Clarke, Melissa S. and Reid, David W. (2016) Use of inhaled corticosteroids in COPD: improving efficacy. Expert Review of Respiratory Medicine, 10 3: 339-350. doi:10.1586/17476348.2016.1151789

Author Yang, Ian A.
Shaw, Janet G.
Goddard, John R.
Clarke, Melissa S.
Reid, David W.
Title Use of inhaled corticosteroids in COPD: improving efficacy
Journal name Expert Review of Respiratory Medicine   Check publisher's open access policy
ISSN 1747-6356
Publication date 2016-03-03
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/17476348.2016.1151789
Open Access Status Not yet assessed
Volume 10
Issue 3
Start page 339
End page 350
Total pages 12
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2017
Language eng
Abstract Chronic obstructive pulmonary disease (COPD) is a chronic, inflammatory lung disease characterized by airflow limitation that is not fully reversible. The pathological changes in COPD lead to alveolar destruction (emphysema) and chronic airway inflammation, resulting in airflow obstruction and recurrent exacerbations. Inhaled corticosteroids (ICS) are anti-inflammatory agents that are widely used, especially in combination with long-acting beta-agonists, in patients with COPD. Here, we will summarize the benefits and risks of ICS use for COPD, and discuss approaches to more personalized medicine when selecting COPD patients to commence (or withdraw) ICS use. The conclusion arising is that further validation of clinical and biological markers should be undertaken in COPD, in order to individualize ICS therapy to maximize efficacy for patients.
Keyword Adverse effects
Chronic obstructive pulmonary disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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