The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume

Lupton, Michelle K., Strike, Lachlan, Hansell, Narelle K., Wen, Wei, Mather, Karen A., Armstrong, Nicola J., Thalamuthu, Anbupalam, McMahon, Katie L., de Zubicaray, Greig I., Assareh, Amelia A., Simmons, Andrew, Proitsi, Petroula, Powell, John F., Montgomery, Grant W., Hibar, Derrek P., Westman, Eric, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, Mecocci, Patrizia, Velas, Bruno, Lovestone, Simon, Brodaty, Henry, Ames, David, Trollor, Julian N., Martin, Nicholas G., Thompson, Paul M., Sachdev, Perminder S. and Wright, Margaret J. (2016) The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiology of Aging, 40 68-77. doi:10.1016/j.neurobiolaging.2015.12.023

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Author Lupton, Michelle K.
Strike, Lachlan
Hansell, Narelle K.
Wen, Wei
Mather, Karen A.
Armstrong, Nicola J.
Thalamuthu, Anbupalam
McMahon, Katie L.
de Zubicaray, Greig I.
Assareh, Amelia A.
Simmons, Andrew
Proitsi, Petroula
Powell, John F.
Montgomery, Grant W.
Hibar, Derrek P.
Westman, Eric
Tsolaki, Magda
Kloszewska, Iwona
Soininen, Hilkka
Mecocci, Patrizia
Velas, Bruno
Lovestone, Simon
Brodaty, Henry
Ames, David
Trollor, Julian N.
Martin, Nicholas G.
Thompson, Paul M.
Sachdev, Perminder S.
Wright, Margaret J.
Title The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 1558-1497
Publication date 2016-04-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2015.12.023
Open Access Status File (Author Post-print)
Volume 40
Start page 68
End page 77
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults
Keyword Alzheimer's disease
Polygenic risk score
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Centre for Advanced Imaging Publications
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