New insights into the genetic regulation of homologue disjunction in mammalian oocytes

Homer, H. (2011) New insights into the genetic regulation of homologue disjunction in mammalian oocytes. Cytogenetic and Genome Research, 133 2-4: 209-222. doi:10.1159/000324118

Author Homer, H.
Title New insights into the genetic regulation of homologue disjunction in mammalian oocytes
Journal name Cytogenetic and Genome Research   Check publisher's open access policy
ISSN 1424-8581
Publication date 2011-04
Year available 2011
Sub-type Article (original research)
DOI 10.1159/000324118
Open Access Status Not yet assessed
Volume 133
Issue 2-4
Start page 209
End page 222
Total pages 14
Place of publication Basel, Switzerland
Publisher S. Karger AG
Language eng
Abstract Mammalian oocytes execute a unique meiotic programme involving 2 arrest stages and an unusually protracted preamble to chromosome segregation during the first meiotic division (meiosis I). How mammalian oocytes successfully navigate their exceptional meiotic journey has long been a question of immense interest. Understanding the minutiae of female mammalian meiosis I is not merely of academic interest as 80-90% of human aneuploidy is the consequence of errors arising at this particular stage of oocyte maturation, a stage with a peculiar vulnerability to aging. Recent evidence indicates that oocytes employ many of the same cast of proteins during meiosis I as somatic cells do during mitosis, often to execute similar tasks, but intriguingly, occasionally delegate them to unexpected and unprecedented roles. This is epitomised by the master cell-cycle regulon, the anaphase-promoting complex or cyclosome (APC/C), acting in concert with a critical APC/C-targeted surveillance mechanism, the spindle assembly checkpoint (SAC). Together, the APC/C and the SAC are among the most influential entities overseeing the fidelity of cell-cycle progression and the precision of chromosome segregation. Here I review the current status of pivotal elements underpinning homologue disjunction in mammalian oocytes including spindle assembly, critical biochemical anaphase-initiating events, APC/C activity and SAC signalling along with contemporary findings relevant to progressive oocyte SAC dysfunction as a model for age-related human aneuploidy. Copyright
Keyword Aneuploidy
Cyclin B
Meiosis I
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
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