Retrotransposons: mobile and mutagenic from conception to death

Faulkner, Geoffrey J. (2011) Retrotransposons: mobile and mutagenic from conception to death. FEBS Letters, 585 11: 1589-1594. doi:10.1016/j.febslet.2011.03.061


Author Faulkner, Geoffrey J.
Title Retrotransposons: mobile and mutagenic from conception to death
Journal name FEBS Letters   Check publisher's open access policy
ISSN 0014-5793
1873-3468
Publication date 2011-06-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.febslet.2011.03.061
Open Access Status Not yet assessed
Volume 585
Issue 11
Start page 1589
End page 1594
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
Mobile genetic elements feature prominently in mammalian genome evolution. Several transposition-competent retrotransposon families (L1, Alu, SVA) remain active in the human germ line, leading to pathogenesis as well as genome structural variation across the global population. High-throughput screening approaches have recently been developed to detect retrotransposon insertion polymorphisms. Evidence produced by these and other genome-scale technologies indicates an expanded role for retrotransposition in human biology, including somatic mobilisation in the developing embryo and in neural cells.
Keyword Alu
Genomics
High-throughput sequencing
L1
Retrotransposon
SVA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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