Protein synthesis in isolated perfused rat skeletal muscle. Contribution of intra- and extracellular amino acid pools

Ward, LC, Buttery, PJ and Boorman, KN (1984) Protein synthesis in isolated perfused rat skeletal muscle. Contribution of intra- and extracellular amino acid pools. International Journal of Biochemistry, 16 10: 1077-1081. doi:10.1016/0020-711X(84)90091-0


Author Ward, LC
Buttery, PJ
Boorman, KN
Title Protein synthesis in isolated perfused rat skeletal muscle. Contribution of intra- and extracellular amino acid pools
Journal name International Journal of Biochemistry   Check publisher's open access policy
ISSN 0020-711X
Publication date 1984
Sub-type Article (original research)
DOI 10.1016/0020-711X(84)90091-0
Volume 16
Issue 10
Start page 1077
End page 1081
Total pages 5
Language eng
Subject 1303 Specialist Studies in Education
Abstract 1. 1. Protein synthesis was measured in perfused rat skeletal muscle using [14C]lysine in the presence of increasing amounts of lysine in the perfusate. 2. 2. The results obtained clearly indicated that both the extracellular and intracellular pools of amino acids act as direct precursors for protein synthesis and analysis of the data, according to O'Hara et al. (J. molec. cell. Cardiol. 13, 925-940, 1981) further indicated that extracellular sources of lysine supplied 64 and 81% of the lysine incorporated in the absence and presence of insulin, respectively. 3. 3. The rate of protein synthesis were assessed to be 0.22 μmol lysine incorporated g-1 muscle per 3 hr of perfusion increasing to 1.0μmol g-1 3hr-1 in the presence of insulin.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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