The reaction of acetaldehyde with brain microtubular proteins: formation of stable adducts and inhibition of polymerization

McKinnon, G, Dejersey, J, Shanley, B and Ward, L (1987) The reaction of acetaldehyde with brain microtubular proteins: formation of stable adducts and inhibition of polymerization. Neuroscience Letters, 79 1-2: 163-168. doi:10.1016/0304-3940(87)90690-2


Author McKinnon, G
Dejersey, J
Shanley, B
Ward, L
Title The reaction of acetaldehyde with brain microtubular proteins: formation of stable adducts and inhibition of polymerization
Journal name Neuroscience Letters   Check publisher's open access policy
ISSN 0304-3940
Publication date 1987-08-18
Sub-type Article (original research)
DOI 10.1016/0304-3940(87)90690-2
Volume 79
Issue 1-2
Start page 163
End page 168
Total pages 6
Language eng
Subject 2800 Neuroscience
Abstract Stable adducts were formed by treatment of bovine brain microtubular proteins (MTP) with acetaldehyde, followed by gel filtration to remove excess acetaldehyde. The extent of stable adduct formation was determined using [14C]acetaldehyde and was correlated with acetaldehyde concentration and reaction time. Significant inhibition of MTP polymerization was observed at adduct concentrations of 0.6 mol acetaldehyde/mol tubulin dimer. The data suggest that repeated exposure of MTP to low concentrations of acetaldehyde, as would occur in the brain and other tissues of alcoholics, may inhibit MTP polymerization with neurological consequences.
Keyword Acetaldehyde
Brain
Microtubular protein
Polymerization
Stable adduct
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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