A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

Stehle, Joerg H., Saade, Anastasia, Rawashdeh, Oliver, Ackermann, Katrin, Jilg, Antje, Sebesteny, Tamas and Maronde, Erik (2011) A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases. Journal of Pineal Research, 51 1: 17-43. doi:10.1111/j.1600-079X.2011.00856.x


Author Stehle, Joerg H.
Saade, Anastasia
Rawashdeh, Oliver
Ackermann, Katrin
Jilg, Antje
Sebesteny, Tamas
Maronde, Erik
Title A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases
Journal name Journal of Pineal Research   Check publisher's open access policy
ISSN 0742-3098
1600-079X
Publication date 2011-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-079X.2011.00856.x
Open Access Status Not Open Access
Volume 51
Issue 1
Start page 17
End page 43
Total pages 27
Place of publication Malden, MA United States
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The human pineal gland is a neuroendocrine transducer that forms an integral part of the brain. Through the nocturnally elevated synthesis and release of the neurohormone melatonin, the pineal gland encodes and disseminates information on circadian time, thus coupling the outside world to the biochemical and physiological internal demands of the body. Approaches to better understand molecular details behind the rhythmic signalling in the human pineal gland are limited but implicitly warranted, as human chronobiological dysfunctions are often associated with alterations in melatonin synthesis. Current knowledge on melatonin synthesis in the human pineal gland is based on minimally invasive analyses, and by the comparison of signalling events between different vertebrate species, with emphasis put on data acquired in sheep and other primates. Together with investigations using autoptic pineal tissue, a remnant silhouette of premortem dynamics within the hormone's biosynthesis pathway can be constructed. The detected biochemical scenario behind the generation of dynamics in melatonin synthesis positions the human pineal gland surprisingly isolated. In this neuroendocrine brain structure, protein-protein interactions and nucleo-cytoplasmic protein shuttling indicate furthermore a novel twist in the molecular dynamics in the cells of this neuroendocrine brain structure. These findings have to be seen in the light that an impaired melatonin synthesis is observed in elderly and/or demented patients, in individuals affected by Alzheimer's disease, Smith-Magenis syndrome, autism spectrum disorder and sleep phase disorders. Already, recent advances in understanding signalling dynamics in the human pineal gland have significantly helped to counteract chronobiological dysfunctions through a proper restoration of the nocturnal melatonin surge.
Keyword Acetylserotonin O-methyltransferase
Arylalkylamine N-acetyltransferase
Autoptic brain tissue
Chronobiology
Clock genes
Melatonin
Neuroendocrine transducer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 16 Mar 2016, 08:52:42 EST by Oliver Rawashdeh on behalf of School of Biomedical Sciences