PERIOD1 coordinates hippocampal rhythms and memory processing with daytime

Rawashdeh, Oliver, Jilg, Antje, Jedlicka, Peter, Slawska, Jolanta, Thomas, Lukas, Saade, Anastasia, Schwarzacher, Stephan W. and Stehle, Joerg H. (2014) PERIOD1 coordinates hippocampal rhythms and memory processing with daytime. Hippocampus, 24 6: 712-723. doi:10.1002/hipo.22262


Author Rawashdeh, Oliver
Jilg, Antje
Jedlicka, Peter
Slawska, Jolanta
Thomas, Lukas
Saade, Anastasia
Schwarzacher, Stephan W.
Stehle, Joerg H.
Title PERIOD1 coordinates hippocampal rhythms and memory processing with daytime
Journal name Hippocampus   Check publisher's open access policy
ISSN 1098-1063
1050-9631
Publication date 2014-06
Sub-type Article (original research)
DOI 10.1002/hipo.22262
Open Access Status Not Open Access
Volume 24
Issue 6
Start page 712
End page 723
Total pages 12
Place of publication Hoboken NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
In species ranging from flies to mammals, parameters of memory processing, like acquisition, consolidation, and retrieval are clearly molded by time of day. However, mechanisms that regulate and adapt these temporal differences are elusive, with an involvement of clock genes and their protein products suggestive. Therefore, we analyzed initially in mouse hippocampus the daytime-dependent dynamics of parameters, known to be important for proper memory formation, like phosphorylation of the “memory molecule” cyclic adenosine monophosphate (cAMP) responsive element binding protein (CREB) and chromatin remodeling. Next, in an effort to characterize the mechanistic role of clock genes within hippocampal molecular dynamics, we compared the results obtained from wildtype (WT) -mice and mice deficient for the archetypical clock gene Period1 (Per1-/--mice). We detected that the circadian rhythm of CREB phosphorylation in the hippocampus of WT mice disappeared completely in mice lacking Per1. Furthermore, we found that the here for the first time described profound endogenous day/night rhythms in histone modifications in the hippocampus of WT-mice are markedly perturbed in Per1-/--mice. Concomitantly, both, in vivo recorded LTP, a cellular correlate for long-term memory, and hippocampal gene expression were significantly altered in the absence of Per1. Notably, these molecular perturbations in Per1-/--mice were accompanied by the loss of daytime-dependent differences in spatial working memory performance. Our data provide a molecular blueprint for a novel role of PER1 in temporally shaping the daytime-dependency of memory performance, likely, by gating CREB signaling, and by coupling to downstream chromatin remodeling.
Keyword Circadian
Learning
CREB
Clock gene
Chromatin
LTP
Epigenetics
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 16 Mar 2016, 08:47:47 EST by Oliver Rawashdeh on behalf of School of Biomedical Sciences