Prenatal exposures to multiple thyroid hormone disruptors: effects on glucose and lipid metabolism

Molehin, Deborah, Dekker Nitert, Marloes and Richard, Kerry (2016) Prenatal exposures to multiple thyroid hormone disruptors: effects on glucose and lipid metabolism. Journal of Thyroid Research, 2016 . doi:10.1155/2016/8765049


Author Molehin, Deborah
Dekker Nitert, Marloes
Richard, Kerry
Title Prenatal exposures to multiple thyroid hormone disruptors: effects on glucose and lipid metabolism
Journal name Journal of Thyroid Research   Check publisher's open access policy
ISSN 2042-0072
2090-8067
Publication date 2016
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2016/8765049
Open Access Status DOI
Volume 2016
Total pages 14
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2017
Language eng
Formatted abstract
Background: Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism. Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism. Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes.

Objectives: This review focuses on the effects of prenatal exposures to combinations of TH-EDCs on fetal and neonatal glucose and lipid metabolism and also discusses the various mechanisms by which TH-EDCs interfere with other hormonal pathways.

Methods: We conducted a comprehensive narrative review on the effects of TH-EDCs with particular emphasis on exposure during pregnancy.

Discussion:
TH imbalance has been linked to many metabolic processes and the effects of TH imbalance are particularly pronounced in early fetal development due to fetal dependence on maternal TH for proper growth and development. The pervasive presence of EDCs in the environment results in ubiquitous exposure to either single or mixtures of EDCs with deleterious effects on metabolism.

Conclusions: Further evaluation of combined effects of TH-EDCs on fetal metabolic endpoints could improve advice provided to expectant mothers.
Keyword Thyroid hormones
TH
Thyroid hormone endocrine disruptors
TH-EDC
Pregnancy
Prenatal exposures
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
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