Can molecular gradients wire the brain?

Goodhill, Geoffrey J. (2016) Can molecular gradients wire the brain?. Trends in Neurosciences, 39 4: 202-211. doi:10.1016/j.tins.2016.01.009

Author Goodhill, Geoffrey J.
Title Can molecular gradients wire the brain?
Journal name Trends in Neurosciences   Check publisher's open access policy
ISSN 1878-108X
Publication date 2016-04
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.tins.2016.01.009
Open Access Status Not Open Access
Volume 39
Issue 4
Start page 202
End page 211
Total pages 10
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Concentration gradients are believed to play a key role in guiding axons to their appropriate targets during neural development. However, there are fundamental physical constraints on gradient detection, and these strongly limit the fidelity with which axons can respond to gradient cues. I discuss these constraints and argue they suggest that many axon guidance events in vivo cannot be explained solely in terms of gradient-based mechanisms. Rather, precise wiring requires the collaboration of gradients with other types of guidance cues. Since we know relatively little about how this might work, I argue that our understanding of how the brain becomes wired up during development is still at an early stage.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
HERDC Pre-Audit
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
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