The role of postoperative radiotherapy for large nerve perineural spread of cancer of the head and neck

Gorayski, Peter, Foote, Matthew, Porceddu, Sandro and Poulsen, Michael (2016) The role of postoperative radiotherapy for large nerve perineural spread of cancer of the head and neck. Journal of Neurological Surgery, Part B: Skull Base, 77 2: 173-181. doi:10.1055/s-0036-1571839


Author Gorayski, Peter
Foote, Matthew
Porceddu, Sandro
Poulsen, Michael
Title The role of postoperative radiotherapy for large nerve perineural spread of cancer of the head and neck
Journal name Journal of Neurological Surgery, Part B: Skull Base   Check publisher's open access policy
ISSN 2193-6331
2193-634X
Publication date 2016-02-26
Year available 2016
Sub-type Article (original research)
DOI 10.1055/s-0036-1571839
Open Access Status Not Open Access
Volume 77
Issue 2
Start page 173
End page 181
Total pages 9
Place of publication New York, NY, United States
Publisher Thieme Medical Publishers
Collection year 2017
Language eng
Abstract Large nerve perineural spread (LNPNS) is an uncommon but serious sequelae of cutaneous and salivary gland malignancies arising in the head and neck. This distinct clinical entity is caused by malignant cell spread along the course of larger (named) cranial nerves in a bidirectional pattern of spread toward the origins of the nerve in the brainstem and/or its most distal branches residing in the dermis. Untreated, LNPNS causes multiple cranial neuropathies that significantly impact on quality of life and ultimately is fatal. Curative treatment involves en bloc surgical resection of all known involved sites of gross disease followed by risk-adapted postoperative radiotherapy (PORT) to improve local control. We review the evidence for contemporary practice and outline the processes involved in the delivery of PORT using the zonal anatomical classification.
Keyword Adenoid cystic carcinoma
Cutaneous
Perineural infiltration
Radiotherapy
Skull base
Squamous cell carcinoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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