LC-MS/MS for therapeutic drug monitoring of anti-infective drugs

Veringa, Anette, Sturkenboom, Marieke G. G., Dekkers, Bart G. J., Koster, Remco A., Roberts, Jason A., Peloquin, Charles A., Touw, Daan J. and Alffenaar, Jan-Willem C. (2016) LC-MS/MS for therapeutic drug monitoring of anti-infective drugs. Trends in Analytical Chemistry, . doi:10.1016/j.trac.2015.11.026

Author Veringa, Anette
Sturkenboom, Marieke G. G.
Dekkers, Bart G. J.
Koster, Remco A.
Roberts, Jason A.
Peloquin, Charles A.
Touw, Daan J.
Alffenaar, Jan-Willem C.
Title LC-MS/MS for therapeutic drug monitoring of anti-infective drugs
Journal name Trends in Analytical Chemistry   Check publisher's open access policy
ISSN 0165-9936
Publication date 2016-02-20
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.trac.2015.11.026
Open Access Status Not Open Access
Total pages 7
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract Therapeutic drug monitoring (TDM) is a tool used to integrate pharmacokinetic and pharmacodynamic knowledge to optimise and personalize drug therapy. TDM is of specific interest for anti-infectives: to assure adequate drug exposure and reduce adverse events, to increase patient compliance and to prevent antimicrobial resistance. For TDM, drug blood concentrations are determined to bring and keep the concentration within the targeted therapeutic range. Currently, LC-MS/MS is the primary analytical technique for fast and accurate quantification of anti-infective drug concentrations. In addition to blood, several alternative matrices (cerebrospinal fluid, inflammatory fluids, specific cells and tissue) and alternative sampling strategies (dried blood spot and saliva) are currently being explored and introduced to support TDM. Here, we review the current challenges in the bioanalysis of anti-infective drugs and give insight in the pre- and postanalytical issues surrounding TDM.
Keyword Anti-infectives
Antimicrobial stewardship (AMS)
Dried blood spot analysis
Free drug concentration
Laboratory proficiency testing
Liquid chromatography-tandem mass spectrometry (LC-MS/MS)
Matrix effects
Pharmacokinetics/pharmacodynamics (PK/PD)
Therapeutic Drug Monitoring (TDM)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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